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Fair Value Measurements - Investments Measured at Fair Value on Recurring Basis (Detail) - USD ($) $ in Millions | Mar. 31, 2021 | Dec. 31, 2020
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Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | $ 1,165.4 | $ 1,069.5
Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 355.8 | 190.3
Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 770.7 | 841.0
Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 38.9 | 38.2
Corporate debt securities |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 409.4 | 445.9
Corporate debt securities | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Corporate debt securities | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 409.4 | 445.9
Corporate debt securities | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Securities of government-sponsored entities |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 268.1 | 312.9
Securities of government-sponsored entities | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Securities of government-sponsored entities | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 268.1 | 312.9
Securities of government-sponsored entities | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total debt securities available-for-sale |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 770.7 | 841.0
Total debt securities available-for-sale | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total debt securities available-for-sale | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 770.7 | 841.0
Total debt securities available-for-sale | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Equity securities–biotechnology industry |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 38.9 | 38.2
Equity securities–biotechnology industry | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Equity securities–biotechnology industry | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Equity securities–biotechnology industry | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 38.9 | 38.2
Total equity securities |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 38.9 | 38.2
Total equity securities | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total equity securities | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total equity securities | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 38.9 | 38.2
Cash and money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 352.6 | 187.1
Cash and money market funds | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 352.6 | 187.1
Cash and money market funds | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Cash and money market funds | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total cash and cash equivalents |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 352.6 | 187.1
Total cash and cash equivalents | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 352.6 | 187.1
Total cash and cash equivalents | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total cash and cash equivalents | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Certificates of deposit |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 3.2 | 3.2
Certificates of deposit | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 3.2 | 3.2
Certificates of deposit | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Certificates of deposit | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total restricted cash |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 3.2 | 3.2
Total restricted cash | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 3.2 | 3.2
Total restricted cash | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Total restricted cash | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 93.2 | 82.2
Commercial paper | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Commercial paper | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 93.2 | 82.2
Commercial paper | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | $ 0.0 | $ 0.0

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