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Fair Value Measurements (Tables)
3 Months Ended
Mar. 31, 2021
Fair Value Disclosures [Abstract]  
Investments Measured at Fair Value on Recurring Basis
Investments at March 31, 2021, which were measured at fair value on a recurring basis, consisted of the following:
Fair Value Measurements Using
(in millions)Fair ValueLevel 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$352.6 $352.6 $— $— 
Total cash and cash equivalents352.6 352.6 — — 
Restricted cash:
Certificates of deposit3.2 3.2 — — 
Total restricted cash3.2 3.2 — — 
Debt securities available-for-sale:
Commercial paper93.2 — 93.2 — 
Corporate debt securities409.4 — 409.4 — 
Securities of government-sponsored entities268.1 — 268.1 — 
Total debt securities available-for-sale770.7 — 770.7 — 
Equity securities:
Equity securities–biotechnology industry38.9 — — 38.9 
Total equity securities38.9 — — 38.9 
Total recurring fair value measurements$1,165.4 $355.8 $770.7 $38.9 
Investments at December 31, 2020, which were measured at fair value on a recurring basis, consisted of the following:
Fair Value Measurements Using
(in millions)Fair ValueLevel 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$187.1 $187.1 $— $— 
Total cash and cash equivalents187.1 187.1 — — 
Restricted cash:
Certificates of deposit3.2 3.2 
Total restricted cash3.2 3.2 
Debt securities available-for-sale:
Commercial paper82.2 82.2 
Corporate debt securities445.9 445.9 
Securities of government-sponsored entities312.9 312.9 
Total debt securities available-for-sale841.0 — 841.0 — 
Equity securities:
Equity securities–biotechnology industry38.2 38.2 
Total equity securities38.2 38.2 
Total recurring fair value measurements$1,069.5 $190.3 $841.0 $38.2 
Reconciliation of Our Investment in Restricted Equity Securities Measured at Fair Value on Recurring Basis Using Significant Unobservable Inputs (Level 3)
The following table presents a reconciliation of equity security investments, which were measured at fair value on a recurring basis using significant unobservable inputs (Level 3):
Three Months Ended
March 31,
(in millions)20212020
Balance at beginning of period$38.2 $55.9 
Unrealized gain (loss) included in earnings0.7 (16.5)
Balance at end of period$38.9 $39.4