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Significant Collaboration and Licensing Agreements - Additional Information (Detail) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	$ 288.9	$ 302.4	$ 525.5	$ 539.5
Product sales, net
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	266.8	267.6	497.8	498.7
Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	1,900.0		1,900.0
Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	1,700.0		1,700.0
Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	1,700.0		1,700.0
Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	1,300.0		1,300.0
BIAL
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	75.0		75.0
BIAL | Product sales, net
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	2.0		3.4
MTPC | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	15.0
Deferred revenue recognized	1.3		2.4	1.3
Deferred revenue, balance	4.4		4.4
Potential milestone payment receipts	55.0		55.0
AbbVie | Royalty
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	5.9	$ 4.8	10.4	$ 9.5
Potential milestone payment receipts	$ 366.0		$ 366.0

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