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Significant Collaboration and Licensing Agreements - Additional Information (Detail) - USD ($) $ / shares in Units, shares in Thousands, $ in Millions		3 Months Ended			9 Months Ended
	Sep. 08, 2021	Sep. 30, 2021	Jun. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Purchases to acquire equity securities					$ 4.6	$ 0.0
Revenues		$ 296.0		$ 258.5	821.5	798.0
Collaborative Arrangement | Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments		1,900.0			1,900.0
Collaborative Arrangement | Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments		1,700.0			1,700.0
Collaborative Arrangement | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments		1,700.0			1,700.0
Milestone payment	$ 10.0
Research and development	$ 4.5
Number of shares owned (in shares)	300
Common stock per share (in USD per share)	$ 19.9755
Milestone purchase payment	$ 5.5
Purchases to acquire equity securities	4.6
Premium paid for equity purchase	$ 0.9
Collaborative Arrangement | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments		1,300.0			1,300.0
Collaborative Arrangement | BIAL
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments		75.0			75.0
Collaborative Arrangement | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred revenue recognized		0.9		0.5	3.3	1.8
Collaborative Arrangement | License | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts		55.0			55.0
Revenues			$ 15.0
Deferred revenue, balance		3.5			3.5
Collaborative Arrangement | Royalty | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts		366.0			366.0
Revenues		$ 5.9		$ 3.9	$ 16.3	$ 13.4

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