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Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Millions | Dec. 31, 2021 | Dec. 31, 2020
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Deferred tax assets: |  |
Net operating losses | $ 90.3 | $ 111.4
Research and development credits | 129.7 | 109.6
Capitalized research and development | 17.9 | 24.7
Share-based compensation expense | 38.9 | 29.8
Operating lease assets | 29.3 | 25.2
Intangible assets | 86.1 | 86.7
Other | 21.6 | 23.9
Total deferred tax assets | 413.8 | 411.3
Deferred tax liabilities: |  |
Convertible senior notes | (9.9) | (13.8)
Operating lease liabilities | (23.3) | (19.9)
Other | (10.7) | (8.4)
Total deferred tax liabilities | (43.9) | (42.1)
Net of deferred tax assets and liabilities | 369.9 | 369.2
Valuation allowance | (54.8) | (49.8)
Net deferred tax assets | $ 315.1 | $ 319.4

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