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Cover Page - USD ($)
 12 Months Ended
Dec. 31, 2021
Feb. 07, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2021    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 0-22705    
Entity Registrant Name NEUROCRINE BIOSCIENCES, INC.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 33-0525145    
Entity Address, Address Line One 12780 El Camino Real,    
Entity Address, City or Town San Diego,    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92130    
City Area Code 858    
Local Phone Number 617-7600    
Title of 12(b) Security Common Stock, $0.001 par value    
Trading Symbol NBIX    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Public Float     $ 9,105,256,378
Entity Common Stock, Shares Outstanding   95,242,683  
Documents Incorporated by Reference Portions of the registrant’s definitive proxy statement relating to the registrant’s annual meeting of stockholders to be filed pursuant to Regulation 14A within 120 days following the end of the registrant’s fiscal year ended December 31, 2021 are incorporated by reference into Part III of this Form 10-K.    
Amendment Flag false    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Entity Central Index Key 0000914475