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Collaboration and License Agreements - Additional Information (Details) - USD ($) $ / shares in Units, shares in Millions, $ in Millions	1 Months Ended	3 Months Ended		12 Months Ended
	Sep. 30, 2021	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				$ 10,900.0
Acquired in-process research and development				105.3	$ 164.5	$ 154.3
Equity securities fair value amount				63.7	38.2
Revenues				1,133.5	1,045.9	788.1
Royalty | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues				22.3	19.2	14.3
Collaborative Arrangement | Heptares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				2,600.0
Acquired in-process research and development				100.0
Collaborative Arrangement | Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				1,900.0
Acquired in-process research and development					120.0
Collaborative Arrangement | Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				1,700.0
Acquired in-process research and development					45.0
Collaborative Arrangement | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				1,700.0
Acquired in-process research and development						36.2
Upfront payments made						$ 30.0
Equity securities number of shares (in shares)	0.3
Share price (in USD per share)	$ 19.9755					$ 14.196
Milestone equity purchase payment						$ 20.0
Equity securities fair value amount	$ 4.6					14.1
Milestone payment	10.0
Research and development	$ 5.4
Collaborative Arrangement | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				1,300.0
Acquired in-process research and development		$ 5.0	$ 113.1
Upfront payments made						$ 115.0
Share price (in USD per share)						$ 11.9625
Milestone equity purchase payment						$ 50.0
Equity securities fair value amount						54.7
Collaborative Arrangement | B I A L
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments				75.0
Research and development					20.0	10.0
Collaborative Arrangement | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts				55.0
Revenues				15.0
Deferred revenue recognized				5.7	2.6	0.9
Deferred revenue				1.0
Collaborative Arrangement | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts				$ 366.0
Revenues					$ 30.0	$ 20.0
Collaborative Arrangement | Patents | Minimum | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term				10 years
Collaborative Arrangement | Patents | Minimum | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term				10 years
Collaborative Arrangement | Common Stock | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Equity securities number of shares (in shares)						1.4
Collaborative Arrangement | Common Stock | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Equity securities number of shares (in shares)						4.2

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