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Income Taxes - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Federal income taxes, rate	21.00%	21.00%	21.00%
Federal income taxes at 21%	$ 21.3	$ 22.4	$ 9.8
State income tax, net of federal benefit	6.2	5.5	4.0
Non-deductible expenses	0.2	0.6	0.8
Branded prescription drug fee	4.8	4.9	3.7
Share-based compensation expense	(11.3)	(6.7)	(12.8)
Officer compensation	7.0	3.7	3.1
Change in tax rate	0.2	3.3	(4.1)
Expired tax attributes	0.6	1.1	1.2
Research credits	(22.0)	(39.0)	(10.4)
Change in valuation allowance	5.0	(296.3)	13.9
Other	(0.2)	(0.1)	0.3
Provision for (benefit from) income taxes	$ 11.8	$ (300.6)	$ 9.5

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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