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Income Taxes - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes [Line Items]
Deferred tax assets, valuation allowance	$ 54.8	$ 49.8
Deferred Tax Assets, Net	315.1	319.4
Research and development tax credit carry forwards	129.7	109.6
Increase related to current year tax positions	4.9	$ 3.9	$ 9.5
Unrecognized tax benefits that would affect effective tax rate	57.4
Federal
Income Taxes [Line Items]
Operating loss carry forward, net	421.1
Research and development tax credit carry forwards	107.3
State and local jurisdiction
Income Taxes [Line Items]
Operating loss carry forward, net	329.9
Research and development tax credit carry forwards	$ 66.3

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Income Taxes [Line Items]

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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