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Fair Value Measurements (Tables)
3 Months Ended
Mar. 31, 2022
Fair Value Disclosures [Abstract]  
Investments Measured at Fair Value on Recurring Basis
The following table presents a summary of investments, which were measured at fair value on a recurring basis.
March 31,
2022
December 31,
2021
Fair
Value
LevelingFair
Value
Leveling
(in millions)Level 1Level 2Level 3Level 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$270.2 $270.2 $— $— $340.8 $340.8 $— $— 
Restricted cash:
Certificates of deposit7.8 7.8 — — 3.2 3.2 — — 
Debt securities available-for-sale:
Commercial paper98.7 — 98.7 — 204.8 — 204.8 — 
Corporate debt securities499.2 — 499.2 — 485.5 — 485.5 — 
Securities of government-sponsored entities337.8 — 337.8 — 240.9 — 240.9 — 
Equity securities:
Equity securities–biotechnology industry91.3 91.3 — — 63.7 52.7 — 11.0 
$1,305.0 $369.3 $935.7 $— $1,338.9 $396.7 $931.2 $11.0 
Reconciliation of Our Investment in Restricted Equity Securities Measured at Fair Value on Recurring Basis Using Significant Unobservable Inputs (Level 3)
The following table presents a reconciliation of equity security investments, which were measured at fair value on a recurring basis using significant unobservable inputs (Level 3).
Three Months Ended
March 31,
(in millions)20222021
Balance at beginning of period$11.0 $38.2 
Unrealized gain included in earnings (1)
20.8 0.7 
Transfers out of Level 3 (2)
(31.8)— 
Balance at end of period$— $38.9 
_________________________
(1) Unrealized gains and losses on restricted equity security investments are included in other income (expense), net.
(2) Our equity security investment in Voyager was transferred from Level 3 to Level 1 as the associated holding period restriction expired.