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Collaboration and License Agreements - Additional Information (Detail) - USD ($) $ / shares in Units, shares in Millions, $ in Millions	3 Months Ended				12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Jun. 30, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	$ 310.6	$ 236.6
Collaborative Arrangement | Heptares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development					$ 100.0
Potential milestone payments	2,600.0
Collaborative Arrangement | Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development						$ 120.0
Potential milestone payments	1,900.0
Collaborative Arrangement | Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development						$ 45.0
Potential milestone payments	1,700.0
Collaborative Arrangement | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront Payments Made							$ 50.0
Acquired in-process research and development							36.2
Potential milestone payments	1,700.0
Equity Securities, FV-NI and without Readily Determinable Fair Value					$ 4.6		$ 14.1
Equity Securities, FV-NI, Cost	$ 7.7
Share price (in USD per share)	$ 31.855				$ 19.9755		$ 14.196
Milestone payment	$ 15.0				$ 10.0
Research and development	$ 7.3				$ 5.4
Collaborative Arrangement | Xenon | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of Stock, Number of Shares Issued in Transaction	0.3				0.3		1.4
Collaborative Arrangement | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront Payments Made							$ 165.0
Acquired in-process research and development			$ 5.0	$ 113.1
Potential milestone payments	$ 1,300.0
Equity Securities, FV-NI and without Readily Determinable Fair Value							$ 54.7
Share price (in USD per share)							$ 11.9625
Collaborative Arrangement | Voyager | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of Stock, Number of Shares Issued in Transaction							4.2
Collaborative Arrangement | BIAL
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	75.0
Collaborative Arrangement | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts	$ 35.0
Collaborative Arrangement | MTPC | Forecast
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Expected milestone payment receipts								$ 20.0
Collaborative Arrangement | MTPC | Minimum | Patents
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term	10 years
Collaborative Arrangement | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts	$ 366.0
Collaborative Arrangement | AbbVie | Minimum | Patents
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term	10 years
Collaborative Arrangement | Royalty | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	$ 4.2	$ 4.5

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