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Collaboration and License Agreements - Additional Information (Details) - USD ($) $ / shares in Units, shares in Millions, $ in Millions | 3 Months Ended | 6 Months Ended | 12 Months Ended
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Jun. 30, 2022 | Mar. 31, 2022 | Jun. 30, 2021 | Jun. 30, 2019 | Mar. 31, 2019 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development | $ 0.0 |  | $ 5.0 |  |  | $ 0.0 | $ 5.0 |  |  |
Revenues | 378.2 |  | 288.9 |  |  | 688.8 | 525.5 |  |  |
Collaborative Arrangement | Heptares |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  | $ 100.0 |  |
Research and development | 30.0 |  |  |  |  |  |  |  |  |
Potential milestone payments | 2,600.0 |  |  |  |  | 2,600.0 |  |  |  |
Collaborative Arrangement | Takeda |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  |  | $ 120.0 |
Potential milestone payments | 1,900.0 |  |  |  |  | 1,900.0 |  |  |  |
Collaborative Arrangement | Idorsia |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  |  | $ 45.0 |
Potential milestone payments | 1,700.0 |  |  |  |  | 1,700.0 |  |  |  |
Collaborative Arrangement | Xenon |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  |  |  | $ 36.2
Research and development |  | $ 7.3 |  |  |  |  |  | $ 5.4 |  |
Potential milestone payments | 1,700.0 |  |  |  |  | 1,700.0 |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  | $ 50.0
Share price (in USD per share) |  | $ 31.855 |  |  |  |  |  | $ 19.9755 |  | $ 14.196
Fair value of equity securities |  |  |  |  |  |  |  | $ 4.6 |  | $ 14.1
Milestone payment |  | $ 15.0 |  |  |  |  |  | $ 10.0 |  |
Equity securities, stock price |  | $ 7.7 |  |  |  |  |  |  |  |
Collaborative Arrangement | Xenon | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Sale of stock (in shares) |  | 0.3 |  |  |  |  |  | 0.3 |  | 1.4
Collaborative Arrangement | Voyager |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  | $ 5.0 | $ 113.1 |  |  |  |  |
Potential milestone payments | 1,300.0 |  |  |  |  | 1,300.0 |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  | $ 165.0
Share price (in USD per share) |  |  |  |  |  |  |  |  |  | $ 11.9625
Fair value of equity securities |  |  |  |  |  |  |  |  |  | $ 54.7
Collaborative Arrangement | Voyager | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Sale of stock (in shares) |  |  |  |  |  |  |  |  |  | 4.2
Collaborative Arrangement | BIAL |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payments | 75.0 |  |  |  |  | 75.0 |  |  |  |
Collaborative Arrangement | MTPC |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payment receipts | 30.0 |  |  |  |  | $ 30.0 |  |  |  |
Revenues | 20.0 |  |  |  |  |  |  |  |  |
Collaborative Arrangement | MTPC | Minimum | Patents |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Patent term |  |  |  |  |  | 10 years |  |  |  |
Collaborative Arrangement | AbbVie |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payment receipts | 366.0 |  |  |  |  | $ 366.0 |  |  |  |
Collaborative Arrangement | AbbVie | Minimum | Patents |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Patent term |  |  |  |  |  | 10 years |  |  |  |
Collaborative Arrangement | Royalty | AbbVie |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues | $ 5.2 |  | $ 5.9 |  |  | $ 9.4 | $ 10.4 |  |  |

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