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Fair Value Measurements - Investments Measured at Fair Value on Recurring Basis (Detail) - USD ($) $ in Millions | Sep. 30, 2022 | Dec. 31, 2021
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Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | $ 1,264.7 | $ 1,338.9
Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 314.9 | 396.7
Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 949.8 | 931.2
Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 11.0
Corporate debt securities |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 521.9 | 485.5
Corporate debt securities | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Corporate debt securities | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 521.9 | 485.5
Corporate debt securities | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Securities of government-sponsored entities |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 330.4 | 240.9
Securities of government-sponsored entities | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Securities of government-sponsored entities | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 330.4 | 240.9
Securities of government-sponsored entities | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Equity securities–biotechnology industry |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 94.9 | 63.7
Equity securities–biotechnology industry | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 94.9 | 52.7
Equity securities–biotechnology industry | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Equity securities–biotechnology industry | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 11.0
Cash and money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 212.2 | 340.8
Cash and money market funds | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 212.2 | 340.8
Cash and money market funds | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Cash and money market funds | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Certificates of deposit |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 7.8 | 3.2
Certificates of deposit | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 7.8 | 3.2
Certificates of deposit | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Certificates of deposit | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair Value | 97.5 | 204.8
Commercial paper | Level 1 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 0.0 | 0.0
Commercial paper | Level 2 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | 97.5 | 204.8
Commercial paper | Level 3 | Fair Value, Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Fair value of assets on recurring basis | $ 0.0 | $ 0.0

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