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Collaboration and License Agreements - Additional Information (Details) - USD ($) $ / shares in Units, shares in Millions, $ in Millions	3 Months Ended						9 Months Ended		12 Months Ended
	Sep. 30, 2022	Jun. 30, 2022	Mar. 31, 2022	Sep. 30, 2021	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development	$ 0.0			$ 0.0			$ 0.0	$ 5.0
Revenues	387.9			296.0			1,076.7	821.5
Collaborative Arrangement | Heptares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development									$ 100.0
Research and development		$ 30.0
Potential milestone payments	2,600.0						2,600.0
Collaborative Arrangement | Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development										$ 120.0
Research and development	5.0
Potential milestone payments	1,900.0						1,900.0
Collaborative Arrangement | Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development										$ 45.0
Potential milestone payments	1,700.0						1,700.0
Collaborative Arrangement | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development											$ 36.2
Research and development			$ 7.3						$ 5.4
Potential milestone payments	1,700.0						1,700.0
Upfront payment											$ 50.0
Share price (in USD per share)			$ 31.855						$ 19.9755		$ 14.196
Fair value of equity securities									$ 4.6		$ 14.1
Milestone payment			$ 15.0						$ 10.0
Equity securities, stock price			$ 7.7
Collaborative Arrangement | Xenon | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of stock (in shares)			0.3						0.3		1.4
Collaborative Arrangement | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Acquired in-process research and development					$ 5.0	$ 113.1
Potential milestone payments	1,300.0						1,300.0
Upfront payment											$ 165.0
Share price (in USD per share)											$ 11.9625
Fair value of equity securities											$ 54.7
Collaborative Arrangement | Voyager | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of stock (in shares)											4.2
Collaborative Arrangement | BIAL
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments	75.0						75.0
Collaborative Arrangement | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues		$ 20.0
Potential milestone payment receipts	30.0						$ 30.0
Collaborative Arrangement | MTPC | Minimum | Patents
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term							10 years
Collaborative Arrangement | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts	366.0						$ 366.0
Collaborative Arrangement | AbbVie | Minimum | Patents
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term							10 years
Collaborative Arrangement | Royalty | AbbVie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues	$ 6.1			$ 5.9			$ 15.5	$ 16.3

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