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Fair Value Measurements - Reconciliation of Equity Securities Measured at Fair Value on Recurring Basis (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Balance at beginning of period | $ 63.7 |  |
Purchases | 7.7 | $ 4.6 | $ 0.0
Unrealized gain (loss) included in earnings | 30.8 | 20.9 | (17.7)
Balance at ending of period | 102.1 | 63.7 |
Level 3 | Fair value measurements recurring | Equity securities–biotechnology industry |  |  |
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Purchases | 0.0 | 4.6 | 0.0
Level 3 | Fair value measurements recurring | Equity securities–biotechnology industry |  |  |
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Balance at beginning of period | 11.0 | 38.2 | 55.9
Unrealized gain (loss) included in earnings | 20.8 | 20.9 | (17.7)
Transfers out of Level 3 | (31.8) | (52.7) | 0.0
Balance at ending of period | $ 0.0 | $ 11.0 | $ 38.2

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- Definition Amount of restricted investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 954 -SubTopic 210 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=127002003&loc=SL6242269-115581 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 954 -SubTopic 210 -Section 45 -Paragraph 4 -URI https://asc.fasb.org/extlink&oid=120413173&loc=SL6242262-115580 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 860 -SubTopic 30 -Section 50 -Paragraph 1A -Subparagraph (b)(1)(i) -URI https://asc.fasb.org/extlink&oid=109249958&loc=SL6224234-111729 + Details
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