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Fair Value Measurements (Tables)
12 Months Ended
Dec. 31, 2022
Fair Value Disclosures [Abstract]  
Investments measured at fair value on recurring basis
The following table presents a summary of investments, which were measured at fair value on a recurring basis.
December 31,
2022
December 31,
2021
Fair
Value
LevelingFair
Value
Leveling
(in millions)Level 1Level 2Level 3Level 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$262.9 $262.9 $— $— $340.8 $340.8 $— $— 
Restricted cash:
Certificates of deposit7.8 7.8 — — 3.2 3.2 — — 
Debt securities available-for-sale:
Commercial paper156.0 — 156.0 — 204.8 — 204.8 — 
Corporate debt securities548.4 — 548.4 — 485.5 — 485.5 — 
Securities of government-sponsored entities321.4 — 321.4 — 240.9 — 240.9 — 
Equity securities:
Equity securities–biotechnology industry102.1 102.1 — — 63.7 52.7 — 11.0 
$1,398.6 $372.8 $1,025.8 $— $1,338.9 $396.7 $931.2 $11.0 
Reconciliation of equity securities measured at fair value on recurring basis using significant unobservable inputs
The following table presents a reconciliation of equity security investments, which were measured at fair value on a recurring basis using significant unobservable inputs (Level 3):
Year Ended December 31,
(in millions)202220212020
Balance at beginning of period$11.0 $38.2 $55.9 
Purchases — 4.6 — 
Unrealized gain (loss) included in earnings (1)
20.8 20.9 (17.7)
Transfers out of Level 3 (2)
(31.8)(52.7)— 
Balance at end of period$— $11.0 $38.2 
_________________________
(1) Unrealized gains and losses on equity security investments which were measured at fair value on a recurring basis using significant unobservable inputs (Level 3) and are included in other income (expense), net.
(2) Certain of our equity security investments were transferred from Level 3 to Level 1 during 2022 and 2021 as the associated holding period restriction expired.