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Collaboration and License Agreements - Additional Information (Details) - USD ($) $ / shares in Units, shares in Millions, $ in Millions	3 Months Ended		12 Months Ended
	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			$ 10,800.0
Acquired in-process research and development			0.0	$ 105.3	$ 164.5
Revenues			1,488.7	1,133.5	1,045.9
Collaborative Arrangement | Heptares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			2,600.0
Acquired in-process research and development				100.0
Research and development			30.0
Collaborative Arrangement | Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			1,900.0
Acquired in-process research and development					120.0
Research and development			5.0
Collaborative Arrangement | Idorsia
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			1,700.0
Acquired in-process research and development					45.0
Collaborative Arrangement | Xenon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			1,700.0
Acquired in-process research and development						$ 36.2
Research and development			$ 7.3	$ 5.4
Upfront payments made						$ 50.0
Share price (in USD per share)			$ 31.855	$ 19.9755		$ 14.196
Equity securities purchase date fair value amount				$ 4.6		$ 14.1
Milestone payment			$ 15.0	$ 10.0
Equity securities cost			$ 7.7
Collaborative Arrangement | Xenon | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of stock (in shares)			0.3	0.3		1.4
Collaborative Arrangement | Voyager
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			$ 1,300.0
Acquired in-process research and development	$ 5.0	$ 113.1
Upfront payments made						$ 165.0
Share price (in USD per share)						$ 11.9625
Equity securities purchase date fair value amount						$ 54.7
Collaborative Arrangement | Voyager | Common Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of stock (in shares)						4.2
Collaborative Arrangement | BIAL – Portela & Ca, S.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments			75.0
Collaborative Arrangement | MTPC
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues			20.0
Potential milestone payment receipts			$ 30.0
Collaborative Arrangement | MTPC | Patents | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term			10 years
Collaborative Arrangement | AbbVie Inc.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payment receipts			$ 366.0
Collaborative Arrangement | AbbVie Inc. | Royalty
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues			$ 21.2	$ 22.3	$ 19.2
Collaborative Arrangement | AbbVie Inc. | Patents | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Patent term			10 years

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