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Fair Value Measurements - Reconciliation of Equity Securities Measured at Fair Value on Recurring Basis (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward]
Balance at beginning of period	$ 63.7
Purchases	7.7	$ 4.6	$ 0.0
Unrealized gain (loss) included in earnings	30.8	20.9	(17.7)
Balance at ending of period	102.1	63.7
Level 3 | Fair value measurements recurring | Equity securities–biotechnology industry
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward]
Purchases	0.0	4.6	0.0
Level 3 | Fair value measurements recurring | Equity securities–biotechnology industry
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward]
Balance at beginning of period	11.0	38.2	55.9
Unrealized gain (loss) included in earnings	20.8	20.9	(17.7)
Transfers out of Level 3	(31.8)	(52.7)	0.0
Balance at ending of period	$ 0.0	$ 11.0	$ 38.2

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- Definition

Amount of restricted investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 210
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- Definition

Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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- Definition

Amount of transfers of financial instrument classified as an asset out of level 3 of the fair value hierarchy.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
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- Definition

The cash outflow to acquire investments (not to include restricted cash) that are pledged or subject to withdrawal restrictions.

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