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Share-Based Compensation - Compensation Cost Related to Share-Based Compensation (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]      
Total stock-based compensation expense $ 173.1 $ 134.2 $ 100.0
Selling, general and administrative expense      
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]      
Total stock-based compensation expense 115.4 85.8 66.3
Research and development expense      
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]      
Total stock-based compensation expense $ 57.7 $ 48.4 $ 33.7