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Income Taxes - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]      
Federal income taxes, rate 21.00% 21.00% 21.00%
Federal income taxes at 21% $ 44.9 $ 21.3 $ 22.4
State income tax, net of federal benefit 11.8 6.2 5.5
Branded prescription drug fee 6.5 4.8 4.9
Loss on extinguishment of convertible senior notes 12.0 0.0 0.0
Stock-based compensation expense (2.5) (11.3) (6.7)
Officer compensation 9.2 7.0 3.7
Change in tax rate (1.3) 0.2 3.3
Expired tax attributes 0.0 0.6 1.1
Research credits (29.9) (22.0) (39.0)
Change in valuation allowance 7.4 5.0 (296.3)
Other 1.3 0.0 0.5
Provision for (benefit from) income taxes $ 59.4 $ 11.8 $ (300.6)