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Income Taxes - Additional Information (Details) - USD ($)	Dec. 31, 2022	Dec. 31, 2021
Income Taxes [Line Items]
Deferred tax assets, valuation allowance	$ 67,000,000	$ 54,800,000
Deferred tax assets	305,900,000	315,100,000
Research and development tax credit carry forwards	108,900,000	$ 129,700,000
Interest accrued	500,000
Penalties accrued	400,000
Unrecognized tax benefits that would affect effective tax rate	74,800,000
State and local jurisdiction
Income Taxes [Line Items]
Operating loss carry forward, net	324,600,000
Research and development tax credit carry forwards	72,500,000
Foreign tax authority
Income Taxes [Line Items]
Operating loss carry forward, net	60,100,000
Federal tax authority
Income Taxes [Line Items]
Operating loss carry forward, net	0
Research and development tax credit carry forwards	$ 98,200,000

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Income Taxes [Line Items]

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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The amount of estimated interest accrued as of the balance sheet date arising from income tax examinations.

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The amount of estimated penalties accrued as of the balance sheet date arising from income tax examinations.

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The total amount of unrecognized tax benefits that, if recognized, would affect the effective tax rate.

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