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Collaboration and License Agreements - Additional Information (Details) $ / shares in Units, shares in Millions, $ in Millions | 3 Months Ended | 12 Months Ended |
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Mar. 31, 2023 USD ($) geneTherapyProgram $ / shares shares | Sep. 30, 2022 USD ($) | Jun. 30, 2022 USD ($) | Mar. 31, 2022 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) $ / shares shares | Dec. 31, 2020 USD ($) non-clinicalStageCompounds | Dec. 31, 2019 USD ($) preclinicalCandidates undisclosedProgram $ / shares shares | Dec. 31, 2022 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development | $ 143.9 |  |  | $ 0.0 |  |  |  |  |  |
Unrealized gain on equity security investments | 2.2 |  |  | 19.9 |  |  |  |  |  |
Equity securities fair value (Level 1) | 135.7 |  |  |  |  |  |  |  |  | $ 102.1
Revenues | $ 420.4 |  |  | 310.6 |  |  |  |  |  |
Collaborative Arrangement | 2023 Voyager Agreement | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Beneficial ownership percentage | 19.90% |  |  |  |  |  |  |  |  |
Collaborative Arrangement | Heptares |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  | $ 100.0 |  |  |
Research and development |  |  | $ 30.0 |  |  |  |  |  |  |
Potential milestone payments | $ 2,600.0 |  |  |  |  |  |  |  |  |
Agreement termination, minimal contractual time |  |  |  |  |  |  | 180 days |  |  |
Agreement termination, contractual time threshold |  |  |  |  |  |  | 90 days |  |  |
Agreement termination by counterparty, contractual time threshold |  |  |  |  |  |  | 365 days |  |  |
Agreement termination by counterparty, minimal contractual time |  |  |  |  |  |  | 120 days |  |  |
Collaborative Arrangement | Takeda |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  | $ 120.0 |  |
Research and development |  | $ 5.0 |  |  |  |  |  |  |  |
Potential milestone payments | 1,900.0 |  |  |  |  |  |  |  |  |
Agreement termination, minimal contractual time |  |  |  |  |  |  |  | 6 months |  |
Agreement termination, contractual time threshold |  |  |  |  |  |  |  | 12 months |  |
Number of non-clinical stage compounds | non-clinicalStageCompounds |  |  |  |  |  |  |  | 4 |  |
Collaborative Arrangement | Idorsia |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  | $ 45.0 |  |
Potential milestone payments | 1,700.0 |  |  |  |  |  |  |  |  |
Agreement termination, minimal contractual time |  |  |  |  |  |  |  | 90 days |  |
Agreement termination, due to material breach |  |  |  |  |  |  |  | 90 days |  |
Collaborative Arrangement | Xenon |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  |  |  | $ 36.2 |
Research and development |  |  |  | $ 7.3 |  |  | $ 5.4 |  |  |
Potential milestone payments | 1,700.0 |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold |  |  |  |  |  |  |  |  | 90 days |
Number of preclinical candidates | preclinicalCandidates |  |  |  |  |  |  |  |  | 3 |
Upfront payment |  |  |  |  |  |  |  |  | $ 50.0 |
Share price (in USD per share) | $ / shares |  |  |  | $ 31.855 |  |  | $ 19.9755 |  | $ 14.196 |
Equity securities fair value (Level 3) |  |  |  |  |  |  | $ 4.6 |  | $ 14.1 |
Milestone payment |  |  |  | $ 15.0 |  |  | $ 10.0 |  |  |
Equity securities fair value (Level 1) |  |  |  | $ 7.7 |  |  |  |  |  |
Collaborative Arrangement | Xenon | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Sale of stock (in shares) | shares |  |  |  | 0.3 |  |  | 0.3 |  | 1.4 |
Collaborative Arrangement | Voyager |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Number of undisclosed programs | undisclosedProgram |  |  |  |  |  |  |  |  | 2 |
Unrealized gain on equity security investments | 9.3 |  |  |  |  |  |  |  |  |
Equity securities fair value (Level 1) | 66.1 |  |  |  |  |  |  |  |  |
Collaborative Arrangement | 2019 Voyager Agreement |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  | $ 5.0 | $ 113.1 |  |  |  |
Potential milestone payments | 1,300.0 |  |  |  |  |  |  |  |  |
Agreement termination, minimal contractual time |  |  |  |  |  |  |  |  | 180 days |
Agreement termination, contractual time threshold |  |  |  |  |  |  |  |  | 1 year |
Upfront payment |  |  |  |  |  | $ 165.0 |  |  |  |
Share price (in USD per share) | $ / shares |  |  |  |  |  | $ 11.9625 |  |  |  |
Equity securities fair value (Level 3) |  |  |  |  |  | $ 54.7 |  |  |  |
Voting restriction period |  |  |  |  |  | 3 years |  |  |  |
Collaborative Arrangement | 2019 Voyager Agreement | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Sale of stock (in shares) | shares |  |  |  |  |  | 4.2 |  |  |  |
Collaborative Arrangement | 2023 Voyager Agreement |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Acquired in-process research and development | 143.9 |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 6,100.0 |  |  |  |  |  |  |  |  |
Agreement termination, minimal contractual time | 180 days |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold | 1 year |  |  |  |  |  |  |  |  |
Upfront payment | $ 175.0 |  |  |  |  |  |  |  |  |
Share price (in USD per share) | $ / shares | $ 8.88 |  |  |  |  |  |  |  |  |
Equity securities fair value (Level 1) | $ 31.3 |  |  |  |  |  |  |  |  |
Voting restriction period |  |  |  |  |  | 3 years |  |  |  |
Number of gene therapy programs | geneTherapyProgram | 3 |  |  |  |  |  |  |  |  |
Board of directors maximum duration term | 10 years |  |  |  |  |  |  |  |  |
Collaborative Arrangement | 2023 Voyager Agreement | Common Stock |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Sale of stock (in shares) | shares | 4.4 |  |  |  |  |  |  |  |  |
Collaborative Arrangement | MTPC |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold | 180 days |  |  |  |  |  |  |  |  |
Revenues |  |  | $ 20.0 |  |  |  |  |  |  |
Potential milestone payment receipts | $ 30.0 |  |  |  |  |  |  |  |  |
Collaborative Arrangement | MTPC | Patents | Minimum |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Patent term | 10 years |  |  |  |  |  |  |  |  |
Collaborative Arrangement | AbbVie |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold | 180 days |  |  |  |  |  |  |  |  |
Potential milestone payment receipts | $ 366.0 |  |  |  |  |  |  |  |  |
Collaborative Arrangement | AbbVie | Royalty |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues | $ 3.7 |  |  | $ 4.2 |  |  |  |  |  |
Collaborative Arrangement | AbbVie | Patents | Minimum |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |
Patent term | 10 years |  |  |  |  |  |  |  |  |

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