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Collaboration and License Agreements - Additional Information (Details) $ / shares in Units, shares in Millions, $ in Millions | 12 Months Ended
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Dec. 31, 2023 USD ($) geneTherapyProgram $ / shares shares | Dec. 31, 2022 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) $ / shares shares | Dec. 31, 2020 non-clinicalStageCompound | Dec. 31, 2019 USD ($) preclinicalCandidate undisclosedProgram $ / shares shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Acquired in-process research and development | $ 143.9 | $ 0.0 | $ 105.3 |  |
Unrealized gain (loss) included in earnings | 28.4 | 30.8 | 20.9 |  |
Equity securities | 161.9 | 102.1 |  |  |
Inventory reserves | 5.2 | 0.0 |  |  |
Revenues | $ 1,887.1 | 1,488.7 | 1,133.5 |  |
Collaborative Arrangement | Common Stock [Member] | Voyager |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Beneficial ownership (as a percent) | 19.90% |  |  |  |
Collaborative Arrangement | Heptares |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Acquired in-process research and development |  |  | $ 100.0 |  |
Research and development |  | 30.0 |  |  |
Potential milestone payments | $ 2,600.0 |  |  |  |
Agreement termination, minimal contractual time (in days) |  |  | 180 days |  |
Agreement termination, contractual time threshold (in days) |  |  | 90 days |  |
Agreement termination by counterparty, contractual time threshold (in days) |  |  | 365 days |  |
Agreement termination by counterparty, minimal contractual time (in days) |  |  | 120 days |  |
Collaborative Arrangement | Takeda |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development |  | 5.0 |  |  |
Potential milestone payments | 1,900.0 |  |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  | 6 months |
Agreement termination, contractual time threshold (in days) |  |  |  | 12 months |
Number of non-clinical stage compounds | non-clinicalStageCompound |  |  |  | 4 |
Collaborative Arrangement | Idorsia |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential milestone payments | 1,700.0 |  |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  | 90 days |
Agreement termination, due to material breach (in days) |  |  |  | 90 days |
Collaborative Arrangement | Xenon |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development |  | $ 7.3 | $ 5.4 |  |
Potential milestone payments | 1,700.0 |  |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  | 90 days
Number of preclinical candidates | preclinicalCandidate |  |  |  |  | 3
Share price (in USD per share) | $ / shares |  | $ 31.855 | $ 19.9755 |  | $ 14.196
Equity securities purchase date fair value amount |  |  | $ 4.6 |  | $ 14.1
Milestone payment |  | $ 15.0 | $ 10.0 |  |
Equity securities cost |  | $ 7.7 |  |  |
Collaborative Arrangement | Xenon | Common Stock [Member] |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sale of stock (in shares) | shares |  | 0.3 | 0.3 |  | 1.4
Collaborative Arrangement | Voyager |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Unrealized gain (loss) included in earnings | 15.5 | $ 14.5 | $ (8.7) |  |
Equity securities | 72.4 |  |  |  |
Collaborative Arrangement | 2019 Voyager Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential milestone payments | $ 1,300.0 |  |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  |  | 180 days
Agreement termination, contractual time threshold (in days) |  |  |  |  | 1 year
Share price (in USD per share) | $ / shares |  |  |  |  | $ 11.9625
Equity securities purchase date fair value amount |  |  |  |  | $ 54.7
Number of undisclosed programs | undisclosedProgram |  |  |  |  | 2
Voting restriction period (in years) | 3 years |  |  |  |
Collaborative Arrangement | 2019 Voyager Agreement | Common Stock [Member] |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sale of stock (in shares) | shares |  |  |  |  | 4.2
Collaborative Arrangement | 2023 Voyager Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Acquired in-process research and development | $ 143.9 |  |  |  |
Potential milestone payments | $ 6,100.0 |  |  |  |
Agreement termination, minimal contractual time (in days) | 180 days |  |  |  |
Agreement termination, contractual time threshold (in days) | 1 year |  |  |  |
Share price (in USD per share) | $ / shares | $ 8.88 |  |  |  |
Equity securities cost | $ 31.3 |  |  |  |
Voting restriction period (in years) | 3 years |  |  |  |
Number of gene therapy programs | geneTherapyProgram | 3 |  |  |  |
Upfront payments made | $ 175.0 |  |  |  |
Board of directors maximum duration term (in years) | 10 years |  |  |  |
Collaborative Arrangement | 2023 Voyager Agreement | Common Stock [Member] |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sale of stock (in shares) | shares | 4.4 |  |  |  |
Collaborative Arrangement | BIAL – Portela & Ca, S.A. |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Inventory reserves | $ 5.2 |  |  |  |
Collaborative Arrangement | MTPC |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Agreement termination, contractual time threshold (in days) | 180 days |  |  |  |
Revenues |  | 20.0 |  |  |
Potential milestone payment receipts | $ 30.0 |  |  |  |
Collaborative Arrangement | MTPC | Patents | Minimum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Patent term (in years) | 10 years |  |  |  |
Collaborative Arrangement | AbbVie Inc. |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Agreement termination, contractual time threshold (in days) | 180 days |  |  |  |
Potential milestone payment receipts | $ 366.0 |  |  |  |
Collaborative Arrangement | AbbVie Inc. | Royalty |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | $ 16.7 | $ 21.2 | $ 22.3 |  |
Collaborative Arrangement | AbbVie Inc. | Patents | Minimum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Patent term (in years) | 10 years |  |  |  |

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Data Type: | na
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