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Insider Trading Arrangements
 3 Months Ended 12 Months Ended
Dec. 31, 2024
shares
Dec. 31, 2024
shares
Trading Arrangements, by Individual    
Material Terms of Trading Arrangement  
During the period from October 1, 2024, to December 31, 2024, our executive officers and directors adopted or terminated contracts, instructions or written plans for the purchase or sale of our securities as noted below:
Name and TitleActionDateTrading Arrangement
Total Shares
Authorized
to be Sold***
Expiration
Date
Rule 10b5-1*Non-Rule 10b5-1**
Stephen A. Sherwin, M.D.
Adoption
11/7/2024X13,831 5/7/2025
Director
Jude Onyia, Ph.D.
Adoption
11/18/2024X89,090 12/31/2025
Chief Scientific Officer
David W. Boyer
Termination
12/11/2024X18,571 2/15/2025
Chief Corporate Affairs Officer
______________
* Intended to satisfy the affirmative defense of Rule 10b5-1(c)
** Not intended to satisfy the affirmative defense of Rule 10b5-1(c)
*** Represents the maximum number of shares that may be sold pursuant to the 10b5-1 arrangement. The number of shares sold is dependent on the satisfaction of certain conditions as set forth in the written plan and the satisfaction of applicable vesting conditions of equity awards.
Non-Rule 10b5-1 Arrangement Adopted false  
Non-Rule 10b5-1 Arrangement Terminated false  
Stephen A. Sherwin [Member]    
Trading Arrangements, by Individual    
Name Stephen A. Sherwin, M.D.  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 11/7/2024  
Expiration Date 5/7/2025  
Arrangement Duration 181 days  
Aggregate Available 13,831 13,831
Jude Onyia [Member]    
Trading Arrangements, by Individual    
Name Jude Onyia, Ph.D.  
Title Chief Scientific Officer  
Rule 10b5-1 Arrangement Terminated true  
Termination Date 11/18/2024  
Expiration Date 12/31/2025  
Arrangement Duration 408 days  
Aggregate Available 89,090 89,090
David W. Boyer [Member]    
Trading Arrangements, by Individual    
Name David W. Boyer  
Title Chief Corporate Affairs Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 12/11/2024  
Expiration Date 2/15/2025  
Arrangement Duration 66 days  
Aggregate Available 18,571 18,571