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Segment Reporting and Disaggregation of Relevant Expense Captions - Segment Reporting Information, by Segment (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Segment Reporting Information [Line Items]      
Revenues $ 2,355.3 $ 1,887.1 $ 1,488.7
Less:      
Cost of revenues 34.0 39.7 23.2
Total research and development 731.1 565.0 463.8
Acquired in-process research and development 12.5 143.9 0.0
Selling, general, and administrative 1,007.2 887.6 752.7
Total operating expenses 1,784.8 1,636.2 1,239.7
Unrealized loss (gain) on equity investments 37.1 (28.4) (30.8)
Charges associated with convertible senior notes 138.4 0.0 70.0
Interest income and other, net (91.0) (52.8) (4.1)
Provision for income taxes 144.7 82.4 59.4
Net income 341.3 249.7 154.5
Reportable Segment      
Segment Reporting Information [Line Items]      
Revenues 2,355.3 1,887.1 1,488.7
Less:      
Cost of revenues 34.0 39.7 23.2
Total research and development 731.1 565.0 463.8
Acquired in-process research and development 12.5 143.9 0.0
Selling, general, and administrative 1,007.2 887.6 752.7
Unrealized loss (gain) on equity investments 37.1 (28.4) (30.8)
Charges associated with convertible senior notes 138.4 0.0 70.0
Interest income and other, net (91.0) (52.8) (4.1)
Provision for income taxes 144.7 82.4 59.4
Net income 341.3 249.7 154.5
Reportable Segment | External research and development      
Less:      
Total research and development 343.5 310.0 213.5
Reportable Segment | Payroll and benefits      
Less:      
Total research and development 236.7 206.7 163.8
Reportable Segment | Milestones      
Less:      
Total research and development 71.7 0.8 42.7
Reportable Segment | Other research and development      
Less:      
Total research and development $ 79.2 $ 47.5 $ 43.8