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Segment Reporting and Disaggregation of Relevant Expense Captions - Segment Reporting Information, by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Segment Reporting Information [Line Items]    
Total revenues $ 572.6 $ 515.3
Less:    
Cost of revenues 9.2 7.5
Total research and development 263.2 159.4
Acquired in-process research and development 0.1 6.0
Selling, general, and administrative 276.5 243.1
Unrealized loss (gain) on equity investments 30.6 (1.6)
Charges associated with convertible senior notes 0.0 88.7
Interest income and other, net (21.7) (22.3)
Provision for (Benefit from) income taxes 6.8 (8.9)
Net income 7.9 43.4
Reportable Segment    
Segment Reporting Information [Line Items]    
Total revenues 572.6 515.3
Less:    
Cost of revenues 9.2 7.5
Total research and development 263.2 159.4
Acquired in-process research and development 0.1 6.0
Selling, general, and administrative 276.5 243.1
Unrealized loss (gain) on equity investments 30.6 (1.6)
Charges associated with convertible senior notes 0.0 88.7
Interest income and other, net (21.7) (22.3)
Provision for (Benefit from) income taxes 6.8 (8.9)
Net income 7.9 43.4
Reportable Segment | INGREZZA Net Product Sales    
Segment Reporting Information [Line Items]    
Total revenues 545.2 506.0
Reportable Segment | CRENESSITY Net Product Sales    
Segment Reporting Information [Line Items]    
Total revenues 14.5 0.0
Reportable Segment | Other revenues    
Segment Reporting Information [Line Items]    
Total revenues 12.9 9.3
Reportable Segment | External research and development    
Less:    
Total research and development 107.9 77.6
Reportable Segment | Payroll and benefits    
Less:    
Total research and development 75.0 57.6
Reportable Segment | Milestones    
Less:    
Total research and development 45.4 6.1
Reportable Segment | Other research and development    
Less:    
Total research and development $ 34.9 $ 18.1