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Collaboration and License Agreements - Additional Information (Details) - Collaborative Arrangement $ / shares in Units, $ in Millions | 3 Months Ended | 6 Months Ended | 12 Months Ended
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Jun. 30, 2025 USD ($) | Mar. 31, 2025 USD ($) | Jun. 30, 2024 USD ($) | Mar. 31, 2024 USD ($) | Mar. 31, 2023 $ / shares shares | Jun. 30, 2025 USD ($) preclinicalCandidate undisclosedProgram geneTherapyProgram non-clinicalStageCompound | Dec. 31, 2022 $ / shares shares | Dec. 31, 2021 $ / shares shares | Dec. 31, 2019 $ / shares shares
Common Stock | Voyager |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Beneficial ownership (as a percent) |  |  |  |  | 19.90% |  |  |  |
Nxera |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and development | $ 15.0 |  | $ 15.0 |  |  |  |  |  |
Potential milestone payments | 2,500.0 |  |  |  |  | $ 2,500.0 |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  |  |  | 180 days |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 90 days |  |  |
Agreement termination by counterparty, contractual time threshold (in days) |  |  |  |  |  | 365 days |  |  |
Agreement termination by counterparty, minimal contractual time (in days) |  |  |  |  |  | 120 days |  |  |
Takeda |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and development |  | $ 37.5 | 7.5 |  |  |  |  |  |
Potential milestone payments | 700.0 |  |  |  |  | $ 700.0 |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  |  |  | 6 months |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 12 months |  |  |
Number of non-clinical stage compounds | non-clinicalStageCompound |  |  |  |  |  | 3 |  |  |
Xenon |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and development | 7.5 |  |  |  |  |  |  |  |
Potential milestone payments | 1,700.0 |  |  |  |  | $ 1,700.0 |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 90 days |  |  |
Number of preclinical candidates | preclinicalCandidate |  |  |  |  |  | 3 |  |  |
Sale of stock (in shares) | shares |  |  |  |  |  |  | 300,000 | 300,000 | 1,400,000
Share price (in USD per share) | $ / shares |  |  |  |  |  |  | $ 31.855 | $ 19.9755 | $ 14.196
2019 Voyager Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and development |  |  |  | $ 5.0 |  |  |  |  |
Potential milestone payments | 500.0 |  |  |  |  | $ 500.0 |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  |  |  | 180 days |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 1 year |  |  |
Share price (in USD per share) | $ / shares |  |  |  |  |  |  |  |  | $ 11.9625
Number of undisclosed programs | undisclosedProgram |  |  |  |  |  | 2 |  |  |
2019 Voyager Agreement | Common Stock |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Sale of stock (in shares) | shares |  |  |  |  |  |  |  |  | 4,200,000
Transfer, beneficial ownership, and voting restrictions period (in years) |  |  |  |  | 3 years |  |  |  |
2023 Voyager Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and development |  |  | $ 3.0 |  |  |  |  |  |
Potential milestone payments | 6,100.0 |  |  |  |  | $ 6,100.0 |  |  |
Agreement termination, minimal contractual time (in days) |  |  |  |  |  | 180 days |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 1 year |  |  |
Share price (in USD per share) | $ / shares |  |  |  |  | $ 8.88 |  |  |  |
Number of gene therapy programs | geneTherapyProgram |  |  |  |  |  | 3 |  |  |
Board of directors maximum duration term (in years) |  |  |  |  | 10 years |  |  |  |
2023 Voyager Agreement | Common Stock |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Sale of stock (in shares) | shares |  |  |  |  | 4,400,000 |  |  |  |
Transfer, beneficial ownership, and voting restrictions period (in years) |  |  |  |  | 3 years |  |  |  |
Sanofi S.A |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 10.0 |  |  |  |  | $ 10.0 |  |  |
Sanofi S.A | Minimum |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Royalties at tiered percentage (as a percent) | 3.00% |  |  |  |  | 3.00% |  |  |
Sanofi S.A | Minimum | Patents |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Patent term (in years) |  |  |  |  |  | 16 years |  |  |
Sanofi S.A | Maximum |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Royalties at tiered percentage (as a percent) | 5.00% |  |  |  |  | 5.00% |  |  |
MTPC |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 180 days |  |  |
Potential milestone payment receipts | $ 30.0 |  |  |  |  | $ 30.0 |  |  |
MTPC | Minimum | Patents |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Patent term (in years) |  |  |  |  |  | 10 years |  |  |
AbbVie |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Agreement termination, contractual time threshold (in days) |  |  |  |  |  | 180 days |  |  |
Potential milestone payment receipts | $ 366.0 |  |  |  |  | $ 366.0 |  |  |
AbbVie | Minimum | Patents |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Patent term (in years) |  |  |  |  |  | 10 years |  |  |

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