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Segment Reporting and Disaggregation of Relevant Expense Captions - Segment Reporting Information, by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
Segment Reporting Information [Line Items]        
Total revenues $ 687.5 $ 590.2 $ 1,260.1 $ 1,105.5
Less:        
Cost of revenues 11.3 9.2 20.5 16.7
Total research and development 244.3 191.1 507.5 350.5
Acquired in-process research and development 0.0 2.5 0.1 8.5
Selling, general, and administrative 286.3 242.0 562.8 485.1
Unrealized loss on equity investments 6.7 19.9 37.3 18.3
Charges associated with convertible senior notes 0.0 49.7 0.0 138.4
Interest income and other, net (20.6) (22.8) (42.3) (45.1)
Provision for income taxes 52.0 33.6 58.8 24.7
Net income 107.5 65.0 115.4 108.4
Reportable Segment        
Segment Reporting Information [Line Items]        
Total revenues 687.5 590.2 1,260.1 1,105.5
Less:        
Cost of revenues 11.3 9.2 20.5 16.7
Total research and development 244.3 191.1 507.5 350.5
Acquired in-process research and development 0.0 2.5 0.1 8.5
Selling, general, and administrative 286.3 242.0 562.8 485.1
Unrealized loss on equity investments 6.7 19.9 37.3 18.3
Charges associated with convertible senior notes 0.0 49.7 0.0 138.4
Interest income and other, net (20.6) (22.8) (42.3) (45.1)
Provision for income taxes 52.0 33.6 58.8 24.7
Net income 107.5 65.0 115.4 108.4
Reportable Segment | INGREZZA net product sales        
Segment Reporting Information [Line Items]        
Total revenues 624.4 579.5 1,169.6 1,085.5
Reportable Segment | CRENESSITY net product sales        
Segment Reporting Information [Line Items]        
Total revenues 53.2 0.0 67.7 0.0
Reportable Segment | Other revenues        
Segment Reporting Information [Line Items]        
Total revenues 9.9 10.7 22.8 20.0
Reportable Segment | External research and development        
Less:        
Total research and development 120.6 89.9 228.5 167.5
Reportable Segment | Payroll and benefits        
Less:        
Total research and development 72.2 54.9 147.2 112.5
Reportable Segment | Milestones        
Less:        
Total research and development 15.1 26.5 60.5 32.6
Reportable Segment | Other research and development        
Less:        
Total research and development $ 36.4 $ 19.8 $ 71.3 $ 37.9