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Segment Reporting and Disaggregation of Relevant Expense Captions - Segment Reporting Information, by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment Reporting Information [Line Items]        
Total revenues $ 794.9 $ 622.1 $ 2,055.0 $ 1,727.6
Less:        
Cost of revenues 14.0 8.0 34.5 24.7
Total research and development 250.0 195.0 757.5 545.5
Acquired in-process research and development 0.3 1.0 0.4 9.5
Selling, general, and administrative 291.6 234.3 854.4 719.4
Unrealized (gain) loss on equity investments (30.6) 16.9 6.7 35.2
Charges associated with convertible senior notes 0.0 0.0 0.0 138.4
Interest income and other, net (22.2) (23.4) (64.5) (68.5)
Provision for income taxes 82.3 60.5 141.1 85.2
Net income 209.5 129.8 324.9 238.2
Reportable Segment        
Segment Reporting Information [Line Items]        
Total revenues 794.9 622.1 2,055.0 1,727.6
Less:        
Cost of revenues 14.0 8.0 34.5 24.7
Total research and development 250.0 195.0 757.5 545.5
Acquired in-process research and development 0.3 1.0 0.4 9.5
Selling, general, and administrative 291.6 234.3 854.4 719.4
Unrealized (gain) loss on equity investments (30.6) 16.9 6.7 35.2
Charges associated with convertible senior notes 0.0 0.0 0.0 138.4
Interest income and other, net (22.2) (23.4) (64.5) (68.5)
Provision for income taxes 82.3 60.5 141.1 85.2
Net income 209.5 129.8 324.9 238.2
Reportable Segment | INGREZZA net product sales        
Segment Reporting Information [Line Items]        
Total revenues 686.6 612.9 1,856.2 1,698.4
Reportable Segment | CRENESSITY net product sales        
Segment Reporting Information [Line Items]        
Total revenues 98.1 0.0 165.8 0.0
Reportable Segment | Other revenues        
Segment Reporting Information [Line Items]        
Total revenues 10.2 9.2 33.0 29.2
Reportable Segment | External research and development        
Less:        
Total research and development 141.8 82.9 370.3 250.4
Reportable Segment | Payroll and benefits        
Less:        
Total research and development 74.6 55.4 221.8 167.9
Reportable Segment | Milestones        
Less:        
Total research and development 1.0 38.8 61.5 71.4
Reportable Segment | Other research and development        
Less:        
Total research and development $ 32.6 $ 17.9 $ 103.9 $ 55.8