<SEC-DOCUMENT>0001415889-25-007433.txt : 20250307
<SEC-HEADER>0001415889-25-007433.hdr.sgml : 20250307
<ACCEPTANCE-DATETIME>20250307165657
ACCESSION NUMBER:		0001415889-25-007433
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250305
FILED AS OF DATE:		20250307
DATE AS OF CHANGE:		20250307

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LEFKOFSKY ERIC P
		CENTRAL INDEX KEY:			0001114357
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-42130
		FILM NUMBER:		25720919

	MAIL ADDRESS:	
		STREET 1:		501 SILVERSIDE ROAD SUITE 87F
		CITY:			WILMONGTON
		STATE:			DE
		ZIP:			19809

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Tempus AI, Inc.
		CENTRAL INDEX KEY:			0001717115
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMPUTER PROGRAMMING, DATA PROCESSING, ETC. [7370]
		ORGANIZATION NAME:           	06 Technology
		IRS NUMBER:				474903308
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		600 WEST CHICAGO AVENUE
		STREET 2:		SUITE 510
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60654
		BUSINESS PHONE:		800-976-5448

	MAIL ADDRESS:	
		STREET 1:		600 WEST CHICAGO AVENUE
		STREET 2:		SUITE 510
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60654

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tempus Labs, Inc.
		DATE OF NAME CHANGE:	20170915
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            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>206</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Black Media, LLC</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>332131</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Lefkofsky Family Foundation</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 14, 2024.</footnote>
        <footnote id="F2">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.60 to $50.59 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14), (15), (16) and (17).</footnote>
        <footnote id="F3">The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC, Gray Media, LLC, and (iii) a trustee of Lefkofsky Family Foundation.</footnote>
        <footnote id="F4">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.60 to $51.59 inclusive.</footnote>
        <footnote id="F5">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.60 to $52.59 inclusive.</footnote>
        <footnote id="F6">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $52.60 to $53.28 inclusive.</footnote>
        <footnote id="F7">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.54 to $50.5399 inclusive.</footnote>
        <footnote id="F8">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.54 to $51.53 inclusive.</footnote>
        <footnote id="F9">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.54 to $52.50 inclusive.</footnote>
        <footnote id="F10">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.13 to $49.12 inclusive.</footnote>
        <footnote id="F11">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.13 to $50.12 inclusive.</footnote>
        <footnote id="F12">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.13 to $51.12 inclusive.</footnote>
        <footnote id="F13">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.13 to $52.10 inclusive.</footnote>
        <footnote id="F14">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.58 to $49.5786 inclusive.</footnote>
        <footnote id="F15">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.58 to $50.5781 inclusive.</footnote>
        <footnote id="F16">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.58 to $51.5769 inclusive.</footnote>
        <footnote id="F17">The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.5871 to $51.7618 inclusive.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Andrew Polovin, Attorney-in-Fact for Eric P. Lefkofsky</signatureName>
        <signatureDate>2025-03-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
