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Property, Plant and Equipment, Net (Tables)
12 Months Ended
Dec. 31, 2018
Property, Plant and Equipment [Abstract]  
Schedule of Property Plant and Equipment Net
 
December 31, 2018

December 31, 2017

 
(in thousands)
Cost
 
 
Land
$
3,476

$
3,464

Building
86,621

88,411

Computer equipment and software
399,192

358,874

Office furniture and fixtures
83,215

78,372

Laboratory equipment
36,092

34,918

Leasehold improvements
25,827

24,097

Motor vehicles
144

42

 
634,567

588,178

Less accumulated depreciation and asset write offs
(475,898
)
(425,127
)
Property, plant and equipment (net)
$
158,669

$
163,051