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Property, Plant and Equipment, Net (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Property, Plant and Equipment [Abstract]    
Land $ 3,476 $ 3,464
Building 86,621 88,411
Computer equipment and software 399,192 358,874
Office furniture and fixtures 83,215 78,372
Laboratory equipment 36,092 34,918
Leasehold improvements 25,827 24,097
Motor vehicles 144 42
Property, plant and equipment, gross 634,567 588,178
Less accumulated depreciation and asset write offs (475,898) (425,127)
Property, plant and equipment (net) $ 158,669 $ 163,051