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v3.21.2

Significant accounting policies (Details) - USD ($) |  | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jul. 17, 2020 | Jun. 30, 2021 | Dec. 31, 2020 | Mar. 09, 2020 | Jan. 01, 2019
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Accounting Standards Update [Extensible List] |  | Accounting Standards Update 2016-02 |  |  |
Change in accounting principle, Accounting Standards Update, transition option elected [Extensible List] |  | us-gaap:AccountingStandardsUpdate201602CumulativeEffectPeriodOfAdoptionMember |  |  |
Operating right-of-use assets |  | $ 69,238,000 | $ 84,561,000 |  |
Operating lease, liability |  | 70,142,000 |  |  |
Opening retained earnings |  | 2,027,943,000 | 1,850,236,000 |  |
Retained Earnings |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Opening retained earnings |  | $ 1,433,882,000 | $ 1,262,895,000 |  |
Accounting Standards Update 2016-02 |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Operating right-of-use assets |  |  |  |  | $ 106,500,000
Operating lease, liability |  |  |  |  | 106,500,000
Accounting Standards Update 2016-02 | Retained Earnings | Cumulative effect, period of adoption, adjustment |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Opening retained earnings |  |  |  |  | $ 0
MeDiNova |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Percentage of interest acquired |  |  |  | 100.00% |
Settlement of liability | $ 43,900,000 |  |  |  |

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