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Significant accounting policies (Details) - USD ($)
 6 Months Ended
Jul. 17, 2020
Jun. 30, 2021
Dec. 31, 2020
Mar. 09, 2020
Jan. 01, 2019
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Accounting Standards Update [Extensible List]   Accounting Standards Update 2016-02      
Change in accounting principle, Accounting Standards Update, transition option elected [Extensible List]   us-gaap:AccountingStandardsUpdate201602CumulativeEffectPeriodOfAdoptionMember      
Operating right-of-use assets   $ 69,238,000 $ 84,561,000    
Operating lease, liability   70,142,000      
Opening retained earnings   2,027,943,000 1,850,236,000    
Retained Earnings          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Opening retained earnings   $ 1,433,882,000 $ 1,262,895,000    
Accounting Standards Update 2016-02          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Operating right-of-use assets         $ 106,500,000
Operating lease, liability         106,500,000
Accounting Standards Update 2016-02 | Retained Earnings | Cumulative effect, period of adoption, adjustment          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Opening retained earnings         $ 0
MeDiNova          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Percentage of interest acquired       100.00%  
Settlement of liability $ 43,900,000