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Business combinations - Fair Value of PRA Health Sciences Inc Acquisition Consideration (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Jul. 01, 2021
Sep. 30, 2021
Sep. 30, 2021
Sep. 30, 2020
Business Acquisition [Line Items]        
Fair value of cash consideration     $ 5,914,475 $ 37,761
Fair value of replacement share-based awards issued to acquiree employees   $ 209,399    
PRA Health Sciences Inc        
Business Acquisition [Line Items]        
Fair value of cash consideration $ 5,308,646      
Fair value of ordinary shares issued to acquiree stockholders 5,658,126      
Fair value of replacement share-based awards issued to acquiree employees 209,399      
Repayment of term loan obligations and accrued interest 865,800      
Total consideration 12,041,971      
Repayments of assumed debt obligtaions $ 401,600