<SEC-DOCUMENT>0001140361-21-022957.txt : 20210630
<SEC-HEADER>0001140361-21-022957.hdr.sgml : 20210630
<ACCEPTANCE-DATETIME>20210630170008
ACCESSION NUMBER:		0001140361-21-022957
CONFORMED SUBMISSION TYPE:	F-4MEF
PUBLIC DOCUMENT COUNT:		10
<REFERENCE-462B>333-254891
FILED AS OF DATE:		20210630
DATE AS OF CHANGE:		20210630
EFFECTIVENESS DATE:		20210630

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ICON PLC
		CENTRAL INDEX KEY:			0001060955
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				981067160

	FILING VALUES:
		FORM TYPE:		F-4MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-257578
		FILM NUMBER:		211062631

	BUSINESS ADDRESS:	
		STREET 1:		SOUTH COUNTY BUSINESS PARK
		STREET 2:		LEOPARDSTOWN
		CITY:			DUBLIN 18
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00 353 1 291 2000

	MAIL ADDRESS:	
		STREET 1:		SOUTH COUNTY BUSINESS PARK
		STREET 2:		LEOPARDSTOWN
		CITY:			DUBLIN 18
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ICON PLC  /ADR/
		DATE OF NAME CHANGE:	20010213
</SEC-HEADER>
<DOCUMENT>
<TYPE>F-4MEF
<SEQUENCE>1
<FILENAME>nt10026444x1_f4mef.htm
<DESCRIPTION>FORM F-4MEF
<TEXT>
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  <div style="text-align: center;"><font style="font-weight: bold;">As filed with the Securities and Exchange Commission on June 30, 2021.</font></div>
  <div style="text-align: right; font-weight: bold;">Registration No. 333-&#160;&#160;&#160;&#160;&#160;&#160; <br>
  </div>
  <div>
    <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">UNITED STATES</div>
  <font style="font-size: 12pt;"> </font>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Washington, D.C. 20549</div>
  <div><br>
  </div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">FORM F-4</div>
  <div style="text-align: center;">REGISTRATION STATEMENT</div>
  <div style="text-align: center;">UNDER</div>
  <div style="text-align: center;">THE SECURITIES ACT OF 1933</div>
  <div><br>
  </div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 20pt; font-weight: bold;">ICON PUBLIC LIMITED COMPANY</div>
  <div style="text-align: center; font-weight: bold;">(Exact Name of Registrant as Specified in its Charter)</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z906a6c938f5f4feda0a3b0862864dc3a" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 33.26%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Ireland</div>
          <div style="text-align: center;">&#160;(State or other jurisdiction of</div>
          <div style="text-align: center;">&#160;incorporation or organization)</div>
        </td>
        <td style="width: 33.26%; vertical-align: bottom;">
          <div style="text-align: center; font-weight: bold;">8731</div>
          <div style="text-align: center;">&#160;(Primary Standard Industrial</div>
          <div style="text-align: center;">&#160;Classification Code Number)</div>
        </td>
        <td style="width: 33.26%; vertical-align: bottom;">
          <div style="text-align: center; font-weight: bold;">Not Applicable</div>
          <div style="text-align: center;">&#160;(IRS Employer</div>
          <div style="text-align: center;">&#160;Identification Number)</div>
        </td>
      </tr>

  </table>
  <div style="text-align: center; font-weight: bold;"> <font style="font-size: 8pt;"><br>
    </font></div>
  <font style="font-size: 8pt;"> </font>
  <div style="text-align: center; font-weight: bold;">South County Business Park</div>
  <div style="text-align: center; font-weight: bold;">Leopardstown</div>
  <div style="text-align: center; font-weight: bold;">Dublin 18, Ireland</div>
  <div style="text-align: center; font-weight: bold;">Tel: +353-1-291-2000</div>
  <div style="text-align: center;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
  <div style="text-align: center; font-weight: bold;"> <font style="font-size: 8pt;"><br>
    </font></div>
  <font style="font-size: 8pt;"> </font>
  <div style="text-align: center; font-weight: bold;">Puglisi &amp; Associates</div>
  <div style="text-align: center; font-weight: bold;">850 Library Avenue, Suite 204</div>
  <div style="text-align: center; font-weight: bold;">Newark, Delaware 19711</div>
  <div style="text-align: center; font-weight: bold;">(302) 738-6680</div>
  <div style="text-align: center;">(Name, address, including zip code, and telephone number, including area code, of agent of service)</div>
  <div><font style="font-size: 6pt;"><br>
    </font> </div>
  <font style="font-size: 6pt;"> </font>
  <div style="text-align: center; font-weight: bold;">With copies to:</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7b6ec97c8a384cc0b1a2180a5ab65b96" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 25.03%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">William M. Hartnett</div>
          <div style="text-align: center; font-weight: bold;">&#160;Kimberly C. Petillo-D&#233;cossard</div>
          <div style="text-align: center; font-weight: bold;">&#160;Ross E. Sturman</div>
          <div style="text-align: center; font-weight: bold;">&#160;Cahill Gordon &amp; Reindel LLP</div>
          <div style="text-align: center; font-weight: bold;">&#160;32 Old Slip</div>
          <div style="text-align: center; font-weight: bold;">&#160;New York, NY 10005</div>
          <div style="text-align: center; font-weight: bold;">&#160;(212) 701-3000</div>
        </td>
        <td style="width: 25.03%; vertical-align: bottom;">
          <div style="text-align: center; font-weight: bold;">Diarmaid Cunningham</div>
          <div style="text-align: center; font-weight: bold;">&#160;General Counsel</div>
          <div style="text-align: center; font-weight: bold;">&#160;ICON plc</div>
          <div style="text-align: center; font-weight: bold;">&#160;South County Business Park</div>
          <div style="text-align: center; font-weight: bold;">&#160;Leopardstown</div>
          <div style="text-align: center; font-weight: bold;">&#160;Dublin 18, Ireland</div>
          <div style="text-align: center; font-weight: bold;">&#160;Tel: +353-1-291-2000</div>
        </td>
        <td style="width: 25.03%; vertical-align: bottom;">
          <div style="text-align: center; font-weight: bold;">Christopher L. Gaenzle</div>
          <div style="text-align: center; font-weight: bold;">&#160;Corporate Secretary</div>
          <div style="text-align: center; font-weight: bold;">&#160;PRA Health Sciences, Inc.</div>
          <div style="text-align: center; font-weight: bold;">&#160;4130 ParkLake Avenue</div>
          <div style="text-align: center; font-weight: bold;">&#160;Suite 400</div>
          <div style="text-align: center; font-weight: bold;">&#160;Raleigh, NC 27612</div>
          <div style="text-align: center; font-weight: bold;">&#160;(919) 786-8200</div>
        </td>
        <td style="width: 25.03%; vertical-align: bottom;">
          <div style="text-align: center; font-weight: bold;">Krishna Veeraraghavan</div>
          <div style="text-align: center; font-weight: bold;">&#160;Laura C. Turano</div>
          <div style="text-align: center; font-weight: bold;">&#160;Paul, Weiss, Rifkind, Wharton &amp;</div>
          <div style="text-align: center; font-weight: bold;">&#160;Garrison LLP</div>
          <div style="text-align: center; font-weight: bold;">&#160;1285 Avenue of the Americas</div>
          <div style="text-align: center; font-weight: bold;">&#160;New York, NY 10019-6064</div>
          <div style="text-align: center; font-weight: bold;">&#160;(212) 373-3000</div>
        </td>
      </tr>

  </table>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <div style="text-align: center; font-weight: bold;">Approximate date of commencement of proposed sale of the securities to the public:</div>
  <div style="text-align: center; font-weight: bold;">As soon as practicable after the effectiveness of this registration statement and upon completion of the merger described in the enclosed joint proxy statement/prospectus.</div>
  <div><br>
  </div>
  <div style="text-align: justify;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the U.S. Securities Act, check the following box and list the U.S. Securities Act registration statement number of the
    earlier effective registration statement for the same offering. &#9746;<font style="font-family: Wingdings;"></font> 333-254891</div>
  <div><br>
  </div>
  <div style="text-align: justify;">If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the U.S. Securities Act, check the following box and list the U.S. Securities Act registration statement number of the earlier effective
    registration statement for the same offering. &#8201; &#9744;</div>
  <div><br>
  </div>
  <div>If applicable, place an X in the box to designate the appropriate rule provision relied upon in conducting this transaction:</div>
  <div><br>
  </div>
  <div>U.S. Exchange Act Rule 13e-4(i) (Cross-Border Issuer Tender Offer) &#8201;&#9744;</div>
  <div><br>
  </div>
  <div>U.S. Exchange Act Rule 14d-1(d) (Cross-Border Third-Party Tender Offer) &#8201;&#9744;</div>
  <div><br>
  </div>
  <div>Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933.</div>
  <div><br>
  </div>
  <div>&#9744; Emerging growth company</div>
  <font style="font-size: 6pt;"> </font>
  <div><br>
  </div>
  <div style="text-align: justify;">If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new
    or revised financial accounting standards&#8224; provided pursuant to Section 7(a)(2)(B) of the Securities Act &#8201;&#9744;</div>
  <div><br>
  </div>
  <div style="text-align: justify;">&#8224;The term &#8216;&#8216;new or revised financial accounting standard&#8217;&#8217; refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5, 2012.</div>
  <div><br>
  </div>
  <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z553eaefbe27449bc8965d5799db4b958" align="left" border="0" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 36%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Title of Each Class of Securities to Be Registered</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Amount to Be</div>
          <div style="text-align: center; font-weight: bold;">&#160;Registered</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Proposed Maximum</div>
          <div style="text-align: center; font-weight: bold;">&#160;Offering Price Per</div>
          <div style="text-align: center; font-weight: bold;">&#160;Share</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Proposed Maximum</div>
          <div style="text-align: center; font-weight: bold;">&#160;Aggregate Offering</div>
          <div style="text-align: center; font-weight: bold;">&#160;Price</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Amount of</div>
          <div style="text-align: center; font-weight: bold;">&#160;Registration</div>
          <div style="text-align: center; font-weight: bold;">&#160;Fee</div>
        </td>
      </tr>
      <tr>
        <td style="width: 36%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">Ordinary shares, par value &#8364;0.06 per share</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">1,168,234<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">N/A</div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">N/A<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
        </td>
        <td style="width: 16.37%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">N/A<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"> (3)</sup></div>
        </td>
      </tr>

  </table>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" align="left" border="0" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 3%; vertical-align: top;">
          <div>(1)</div>
        </td>
        <td style="width: 97%; vertical-align: top;">
          <div style="text-align: justify;">Represents the estimated maximum number of additional ordinary shares, par value &#8364;0.06 each (&#8220;ICON ordinary shares&#8221;), of ICON plc (the &#8220;Registrant&#8221;) issuable upon the completion of the merger transactions
            described herein. The Registrant has previously registered 28,831,766 ICON ordinary shares pursuant to the registration statement on Form F-4 (Registration No. 333-254891) as amended through Amendment No. 1 to Form F-4 (Registration No.
            333-254891), filed on April 26, 2021 (the &#8220;Prior Registration Statement&#8221;), and declared effective on April 27, 2021. The Registrant now estimates that up to 30,000,000<font style="font-weight: bold;">&#160;</font>ICON ordinary shares may be issued
            upon completion of the merger described in the Prior Registration Statement and that 232,620 fewer shares of PRA common stock will be exchanged in the merger.</div>
        </td>
      </tr>
      <tr>
        <td style="width: 3%; vertical-align: top;">
          <div>(2)</div>
        </td>
        <td style="width: 97%; vertical-align: top;">
          <div style="text-align: justify;">Pursuant to Rules 457(c), 457(f)(1) and 457(f)(3) promulgated under the Securities Act and solely for the purpose of calculating the registration fee,&#160; the proposed maximum aggregate offering price of the
            additional ICON ordinary shares covered hereby is nil because the calculation of the registration fee in this registration statement is based on fewer shares of PRA common stock than the registration fee calculation in the Prior Registration
            Statement.</div>
        </td>
      </tr>
      <tr>
        <td style="width: 3%; vertical-align: top;">
          <div>(3)</div>
        </td>
        <td style="width: 97%; vertical-align: top;">
          <div style="text-align: justify;">The registration fee for the securities registered hereby has been calculated pursuant to Section 6(b) of the Securities Act, by multiplying the proposed maximum aggregate offering price for the securities by
            0.0001091. A registration fee of $518,500.31 was paid in connection with the Prior Registration Statement and no additional registration fee is due herewith.</div>
        </td>
      </tr>

  </table>
  <div style="clear: both;"> <br>
  </div>
  <div>This registration statement will become effective automatically upon filing with the Commission pursuant to Rule 462(b) under the Securities Act of 1933, as amended.&#160;</div>
  <div><br>
  </div>
  <div>
    <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageBreak" style="page-break-after: always;">
      <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
  </div>
  <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
  <div><br>
  </div>
  <div style="text-indent: 20pt;">Pursuant to its Registration Statement on Form F-4 (Registration No. 333-254891), filed on March 31, 2021, as amended through Amendment No. 1 to Form F-4 (Registration No. 333-254891), filed on April 26, 2021 (the &#8220;Prior
    Registration Statement&#8221;),&#160; and declared effective as of April 27, 2021, ICON plc, a company incorporated under the laws of Ireland (the &#8220;Registrant&#8221;), registered an aggregate of 28,831,766 of its ordinary shares, par value &#8364;0.06 each (&#8220;ICON ordinary
    shares&#8221;), and paid an aggregate registration fee of $518,500.31. This Registration Statement is being filed with the Securities and Exchange Commission pursuant to General Instruction H of Form F-4 and Rule 462(b) of the Securities Act of 1933, as
    amended, for the sole purpose of registering an additional 1,168,234 ICON ordinary shares estimated to be issuable upon the completion of the merger described in the Prior Registration Statement.</div>
  <div><br>
  </div>
  <div style="text-align: center; text-indent: 20pt; font-weight: bold;">STATEMENT OF INCORPORATION BY REFERENCE</div>
  <div><br>
  </div>
  <div style="text-indent: 20pt;">This registration statement incorporates by reference the contents of the Prior Registration Statement including all amendments, supplements and exhibits thereto and all information incorporated or deemed to be
    incorporated by reference therein. Additional opinions and consents required to be filed with this Registration Statement are listed on the Exhibit Index included with this Registration Statement.</div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageBreak" style="page-break-after: always;">
      <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
  </div>
  <div style="text-align: center; font-weight: bold;">EXHIBIT INDEX</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z375d13478f6141cc9cbb50b93ee7a54b" align="left" border="0" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 10%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Exhibit</div>
          <div style="text-align: center; font-weight: bold;"> Number</div>
        </td>
        <td style="width: 2%; vertical-align: middle; padding-bottom: 2px;">
          <div>&#8203;</div>
        </td>
        <td style="width: 88%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-weight: bold;">Description</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="nt10026444x1_ex5-1.htm">5.1</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Opinion of A&amp;L Goodbody LLP, dated June 30, 2021, as to the validity of the ordinary shares of ICON plc being registered pursuant to this registration statement</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="nt10026444x1_ex23-1.htm">23.1</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Consent of KPMG, Independent Registered Public Accounting Firm, relating to the financial statements of ICON plc</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="nt10026444x1_ex23-2.htm">23.2</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Consent of Deloitte &amp; Touche LLP relating to the financial statements of PRA Health Sciences, Inc.</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="nt10026444x1_ex5-1.htm">23.3</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Consent of A&amp;L Goodbody LLP (included in Exhibit 5.1)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1060955/000114036121010936/nt10020839x1_f4.htm#tSIG">24.1</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Power of Attorney of Officers and Directors (included on the signature page of the registration statement filed on March 31, 2021)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 10%; vertical-align: top;">
          <div style="text-align: center;"><a href="nt10026444x1_ex99-1.htm">99.1</a></div>
        </td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 88%; vertical-align: bottom;">
          <div style="text-align: justify;">Consent of Centerview Partners LLC</div>
        </td>
      </tr>
      <tr>
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          <div style="text-align: center;"><a href="nt10026444x1_ex99-2.htm">99.2</a></div>
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          <div style="text-align: center;"><a href="nt10026444x1_ex99-3.htm">99.3</a></div>
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  <div style="clear: both;"><br>
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  <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
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  <div style="text-align: justify; text-indent: 20pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in
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      <tr>
        <td style="width: 45%; vertical-align: top;">&#160;</td>
        <td style="width: 5%; vertical-align: middle;">&#160;</td>
        <td style="width: 45%; vertical-align: middle;">&#160;</td>
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      <tr>
        <td style="width: 45%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 45%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 45%; vertical-align: top;">&#160;</td>
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  <div style="clear: both;"><br>
  </div>
  <div><br>
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  <div style="text-align: justify; text-indent: 20pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the date indicated.</div>
  <div style="text-align: justify; text-indent: 20pt;"> <br>
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      <tr>
        <td rowspan="1" style="width: 31%; vertical-align: top;">&#160;</td>
        <td rowspan="1" style="width: 2%; vertical-align: middle;">&#160;</td>
        <td rowspan="1" style="width: 34%; vertical-align: bottom; text-align: center;">&#160;</td>
        <td rowspan="1" style="width: 2%; vertical-align: middle;">&#160;</td>
        <td rowspan="1" style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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          <div>&#8203;</div>
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          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Ciaran Murray</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
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        <td rowspan="2" style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Dr. Steve Cutler</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Brendan Brennan</div>
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        <td rowspan="2" style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td rowspan="2" style="width: 34%; vertical-align: top;">
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Brendan Brennan</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">R&#243;n&#225;n Murphy</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
        </td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Professor Hugh Brady</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
        </td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Dr. John Climax</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
        </td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Joan Garahy</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
        </td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      </tr>
      <tr>
        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">Eugene McCague</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">*</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center;">Director</div>
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          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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          <div style="text-align: center;">Julie O&#8217;Neill</div>
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          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">
          <div style="text-align: center;">June 30, 2021</div>
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      <tr>
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          <div style="text-align: center;">Mary Pendergast</div>
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        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">
          <div>&#8203;</div>
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        <td style="width: 31%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;">&#160;</td>
        <td style="width: 31%; vertical-align: top;">&#160;</td>
      </tr>

  </table>
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          <div style="font-family: 'Times New Roman',Times,serif;">&#8203;</div>
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          <div>/s/ Brendan Brennan</div>
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        <td style="width: 63%; vertical-align: top;">&#160;</td>
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  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold; clear: both;">AUTHORIZED REPRESENTATIVE</div>
  <div><br>
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  <div style="font-weight: bold;">Puglisi &amp; Associates</div>
  <div style="font-weight: bold;"> <br>
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          <div style="text-align: center;">&#160;/s/ Donald J. Puglisi </div>
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          <div style="text-align: center;">&#160;</div>
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          <div style="text-align: center;">&#160;</div>
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          <div style="text-align: center;">&#160;&#160;June 30, 2021</div>
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        <td style="width: 33%;">
          <div style="text-align: center;">&#160;Donald J. Puglisi</div>
        </td>
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          <div style="text-align: center;">&#160;Managing Director, Puglisi &amp; Associates</div>
        </td>
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          <div style="text-align: center;">&#160;</div>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>nt10026444x1_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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  <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 5.1</font><br>
  </div>
  <br>
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          <div><img src="nt10026444x1_ex5-1img02.jpg" height="28" width="188"></div>
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        <td style="width: 13%; vertical-align: top;">&#160;</td>
        <td colspan="1" style="width: 1%; vertical-align: top; font-weight: bold; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 35%; vertical-align: top; font-weight: bold;">
          <div style="text-align: justify;">&#160;A&amp;L Goodbody</div>
        </td>
        <td style="width: 15%; vertical-align: top;">
          <div style="text-align: right;">Dublin</div>
        </td>
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        <td style="width: 13%; vertical-align: top;">&#160;</td>
        <td colspan="1" style="width: 1%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="text-align: justify;">&#160;International Financial Services Centre</div>
        </td>
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          <div style="text-align: right;">Belfast</div>
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        <td style="width: 13%; vertical-align: top;">&#160;</td>
        <td colspan="1" style="width: 1%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 35%; vertical-align: top;">
          <div style="text-align: justify;">&#160;25-28 North Wall Quay, Dublin 1</div>
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        <td style="width: 15%; vertical-align: top;">
          <div style="text-align: right;">London</div>
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        <td colspan="1" style="width: 1%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="text-align: justify;">&#160;D01 H104</div>
        </td>
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          <div style="text-align: right;">New York</div>
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        <td style="width: 13%; vertical-align: top;">&#160;</td>
        <td colspan="1" style="width: 1%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 35%; vertical-align: top;">
          <div style="text-align: justify;">&#160;T: +353 1 649 2000</div>
        </td>
        <td style="width: 15%; vertical-align: top;">
          <div style="text-align: right;">San Francisco</div>
        </td>
      </tr>
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        <td style="width: 13%; vertical-align: top;">&#160;</td>
        <td colspan="1" style="width: 1%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 35%; vertical-align: top;">
          <div style="text-align: justify;">&#160;DX: 29 Dublin | www.algoodbody.com</div>
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        <td style="width: 15%; vertical-align: top;">
          <div style="text-align: right;">Palo Alto</div>
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          <div>&#160;Date</div>
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          <div>&#160;&#160;&#160; 30 June 2021<br>
          </div>
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          <div>&#160;</div>
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          <div>&#160;&#160; <br>
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          <div>&#160;Our ref<br>
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          <div>&#160;&#160;&#160; BHY/BOF 01435880</div>
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  <div style="text-align: justify;"> ICON plc<br>
  </div>
  <div style="text-align: justify;">South County Business Park<br>
  </div>
  <div style="text-align: justify;">Leopardstown<br>
  </div>
  <div style="text-align: justify;">Dublin 18<br>
  </div>
  <div style="text-align: justify;">Ireland<br>
  </div>
  <div style="text-align: justify;"> <br>
  </div>
  <div style="text-align: justify;"><font style="font-weight: bold;">ICON plc</font> (the <font style="font-weight: bold;">Company</font>)<br>
  </div>
  <br>
  <div style="text-align: justify;">Dear Sirs</div>
  <div><br>
  </div>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Context</div>
        </td>
      </tr>

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        <td style="width: 31.2pt; vertical-align: top; align: right;">1.1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>We act as Irish counsel for the Company, registered number 145835, a public limited company limited by shares incorporated under the laws of Ireland, in connection with the Registration Statement on Form F-4, which includes the Joint Proxy
            Statement/Prospectus, filed with the United States Securities and Exchange Commission (the <font style="font-weight: bold;">SEC</font>) in or around 31 March 2021, under the Securities Act of 1933, as amended (such Registration Statement, as
            amended or supplemented, is hereinafter referred to as the <font style="font-weight: bold;">Registration Statement</font>).</div>
        </td>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">1.2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>In connection with the transactions contemplated by an Agreement and Plan of Merger, dated as of February 24, 2021, by and among the Company, ICON US Holdings, Inc., Indigo Merger Sub, Inc. and PRA Health Sciences, Inc. (the <font style="font-weight: bold;">Merger Agreement</font>), the Company originally expected to issue approximately 28,831,766 ordinary shares, par value &#8364;0.06 per share, such number being an estimate as of 30 March 2021. It has since been updated
            such that the Company now expects to issue up to approximately 30,000,000 ordinary shares, par value &#8364;0.06 per share, in aggregate. Such shares, when issued in accordance with the Merger Agreement, are referred to in this opinion as the <font style="font-weight: bold;">Merger Shares</font> and the issuance of the Merger Shares is referred to as the <font style="font-weight: bold;">Issuance</font>.</div>
        </td>
      </tr>

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  <div><br>
  </div>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Examination</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div style="text-align: justify; margin-left: 31.2pt;">In connection with this opinion, we have reviewed copies of such corporate records and other instruments of the Company as we have deemed necessary as a basis for the opinion as set out in paragraph
    3 of this letter, including:</div>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zeab150d880b748d793f3c89b4f0f9c81" cellpadding="0" cellspacing="0">

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        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">(i)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Merger Agreement;</div>
        </td>
      </tr>

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  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z737eaa0182304170844b998a66abea28" cellpadding="0" cellspacing="0">

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        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">(ii)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Registration Statement;</div>
        </td>
      </tr>

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  <div><br>
  </div>
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        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">(iii)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>resolutions of the board of directors of the Company approving, amongst other things, the Merger Agreement and the Issuance;</div>
        </td>
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  <div><br>
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  <div><br>
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  <div><br>
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    <div style="text-align: center;"><img src="nt10026444x1_ex5-1img01.jpg" height="121" align="middle" border="0" width="845"> </div>
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        <td style="width: 36.85pt; vertical-align: top; align: right;">(iv)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>notice of an extraordinary general meeting of the Company setting out the resolutions passed by the shareholders approving the Issuance (the <font style="font-weight: bold;">EGM Resolutions</font>), as contained in the Registration
            Statement;</div>
        </td>
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  <div><br>
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  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7782dac54c8446d7b136711a88ba7cb6" cellpadding="0" cellspacing="0">

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        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">(v)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>a copy of the Constitution of the Company, in force as of the date hereof (the <font style="font-weight: bold;">Constitution</font>).</div>
        </td>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">3</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Opinion</div>
        </td>
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  <div><br>
  </div>
  <div style="text-align: justify; margin-left: 31.2pt;">Based upon and subject to the assumptions, qualifications and limitations set out below, we are of the opinion that:</div>
  <div><br>
  </div>
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        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">(i)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Company is a public company limited by shares and is duly incorporated and validly existing under the laws of Ireland; and</div>
        </td>
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        <td style="width: 36.85pt; vertical-align: top; align: right;">(ii)</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Merger Shares, when issued by the Company in accordance with the terms of the Registration Statement and the Merger Agreement, will have been duly authorised and will be validly issued, fully paid and non-assessable (which term means
            that no further sums are required to be paid by the holders thereof in connection with the issue of such Merger Shares).</div>
        </td>
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  <div><br>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">4</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Assumptions</div>
        </td>
      </tr>

  </table>
  <div><br>
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        <td style="width: 31.2pt; vertical-align: top; align: right;">4.1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>In rendering this opinion, we have examined, and have assumed the truth and accuracy of the contents of, such documents and certificates of officers of the Company and of public officials as to factual matters and have conducted such
            searches in public registries in Ireland as we have deemed necessary or appropriate for the purposes of this opinion.</div>
        </td>
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  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z67d301c6d4e14871b498639a8f030b73" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt; vertical-align: top; align: right;">4.2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>We have assumed that when the Issuance occurs:</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9b0ad4536f0143ffb7ea9fd328898d50" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.2.1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Constitution has not been amended or varied;</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zaa409358fd3f4d10a453887cb5cb35a8" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.2.2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Registration Statement has become effective;</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc49fa024cf3949619e673b7e0b741066" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.2.3</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the Company is fully solvent at the time of and immediately following the Issuance (ii) no resolution or petition for the appointment of a liquidator or examiner has been presented prior to the Issuance (iii) no receiver will have been
            appointed in relation to any of the assets or undertaking of the Company and (iv) no composition in satisfaction of debts, scheme of arrangement, or compromise or arrangement with any creditors or members will be proposed, sanctioned or
            approved in relation to the Company.</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z558ae6384f734adb91aeec1004e8c6ed" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt; vertical-align: top; align: right;">4.3</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>We have further assumed:</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z55a93c46be4b443ca51a953428e8bb44" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.3.1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the authenticity of all documents submitted to us, the conformity to the originals of all documents submitted to us as copies and the authenticity of the originals of all documents submitted to us as copies;</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb21160917a91437e91ad864904ec0f2a" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.3.2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>the authority of persons signing on behalf of a particular party and the due authorisation, execution and delivery of all documents by the parties thereto other than the Company; and</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7edc55e8503c42e9ad36e7ac21877710" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt;"><br>
        </td>
        <td style="width: 36.85pt; vertical-align: top; align: right;">4.3.3</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>that none of the EGM Resolutions and authorities of the shareholders or directors of the Company upon which we have relied have been varied, amended or revoked in any respect or have expired and that the Merger Shares will be issued in
            accordance with such resolutions and authorities and the terms of the Merger Agreement.</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageNumberArea" style="text-align: right;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
    <div id="DSPFPageBreak" style="page-break-after: always;">
      <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
  </div>
  <div> <img src="nt10026444x1_img01.jpg"></div>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z651b145627dc46f09eccb0e2e571acc7" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt; vertical-align: top; align: right;">5</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Qualifications</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z178527cfc7c64cdd948b6b92c4f60858" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt; vertical-align: top; align: right;">5.1</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>This opinion is limited to the specific issues addressed herein, and no opinion may be inferred or implied beyond that expressly stated herein.</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6ed9e36a9e3a409594a66070ac66ad5f" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 31.2pt; vertical-align: top; align: right;">5.2</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div>This opinion is confined to and given in all respects on the basis of the laws of Ireland (meaning Ireland exclusive of Northern Ireland) in force as at the date of this opinion as currently applied by the courts of Ireland. We have made no
            investigations of, and we express no opinion as to the laws of, any other jurisdiction or their effect on this opinion. This opinion speaks only as of its date. We assume no obligation to update this opinion at any time in the future or to
            advise you of any change in law or change in interpretation of law which may occur after the date of this opinion.</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div style="text-align: justify;">We hereby consent to the filing of this opinion with the SEC.</div>
  <div><br>
  </div>
  <div style="text-align: justify;">Yours faithfully</div>
  <div><br>
  </div>
  <div>/s/ A&amp;L Goodbody </div>
  <div style="text-align: justify; font-weight: bold;">A&amp;L Goodbody</div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div id="DSPFPageNumberArea" style="text-align: right;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">3</font>
    <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>nt10026444x1_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.5.1.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div>
      <div style="text-align: right; font-weight: bold;">Exhibit 23.1</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Consent of Independent Registered Public Accounting Firm</div>
      <div><br>
      </div>
      <div style="text-align: justify;">We consent to the use of our reports dated February 24, 2021, with respect to the consolidated financial statements of ICON plc and subsidiaries, and the
        effectiveness of internal control over financial reporting, incorporated herein by reference and to the reference to our firm under the heading &#8220;Experts&#8221; in the prospectus
          on Form F-4, incorporated herein by reference.</div>
      <div><br>
      </div>
      <div>/s/ KPMG</div>
      <div><br>
      </div>
      <div>Dublin, Ireland</div>
      <div>June 30, 2021</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div>
        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>4
<FILENAME>nt10026444x1_ex23-2.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.5.1.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 23.2</font><br>
    </div>
  </div>
  <div> <br>
  </div>
  <div>
    <div style="margin-left: 5pt; font-weight: bold;"> <br>
    </div>
    <div style="margin-left: 5pt; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
    <div style="margin-left: 5pt; font-weight: bold;"> <br>
    </div>
    <div style="margin-right: 2.25pt; margin-left: 5pt;">We consent to the incorporation by reference in this Registration Statement on Form F-4 of our reports dated February
      24, 2021, relating to the financial statements of PRA Health Sciences, Inc. and the effectiveness of the PRA Health Sciences, Inc. internal control over financial reporting, appearing in the Annual Report on Form 10-K of PRA Health Sciences, Inc. for
      the year ended December 31, 2020. We also consent to the reference to us under the heading &#8220;Experts&#8221; in such Registration Statement.</div>
    <div><br>
    </div>
    <div style="margin-left: 5pt;">/s/ Deloitte &amp; Touche LLP</div>
    <div><br>
    </div>
    <div style="margin-left: 5pt;">Raleigh, North Carolina</div>
    <div style="margin-left: 5pt;">June 30, 2021</div>
    <div style="margin-left: 5pt;"> <br>
    </div>
    <div style="margin-left: 5pt;"> <br>
    </div>
    <div style="margin-left: 5pt;">
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>5
<FILENAME>nt10026444x1_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.5.1.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 99.1</font><br>
    </div>
  </div>
  <div> <br>
  </div>
  <div>
    <div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Consent of Centerview Partners LLC</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif;">The Board of Directors</div>
      <div style="font-family: 'Times New Roman',Times,serif;">ICON plc</div>
      <div style="font-family: 'Times New Roman',Times,serif;">South County Business Park</div>
      <div style="font-family: 'Times New Roman',Times,serif;">Leopardstown</div>
      <div style="font-family: 'Times New Roman',Times,serif;">Dublin 18, Ireland</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif;">The Board of Directors:</div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">We hereby consent to the inclusion of our opinion letter, dated February 23, 2021, to the Board of Directors of ICON plc (&#8220;<u>Parent</u>&#8221;), as Annex B to, and reference to
        such opinion letter under the headings &#8220;SUMMARY &#8211; Opinion of ICON&#8217;s Financial Advisor&#8221;, &#8220;THE MERGER &#8211; ICON&#8217;s Reasons for the Merger&#8221; and &#8220;THE MERGER &#8211; Opinion of ICON&#8217;s Financial Advisor&#8221; in, the proxy statement/prospectus relating to the proposed
        transaction involving Parent and PRA Health Sciences, Inc. (the &#8220;<u>Company</u>&#8221;), which proxy statement/prospectus forms a part of the Registration Statement on Form&#160;F-4 of Parent to register additional securities for an offering pursuant to Rule
        462(b) under the Securities Act of 1933 (the &#8220;<u>Registration Statement</u>&#8221;). In giving such consent, we do not admit that we come within the category of persons whose consent is required under Section&#160;7 of the Securities Act of 1933, as amended,
        or the rules and regulations of the Securities and Exchange Commission promulgated thereunder nor do we hereby admit that we are experts with respect to any part of the Registration Statement within the meaning of the term &#8220;experts&#8221; as used in the
        Securities Act of 1933, as amended, or the rules and regulations of the Securities and Exchange Commission promulgated thereunder.</div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="font-family: 'Times New Roman',Times,serif;">&#160;
        <table id="zc859ef005d5e462b98921b434934f2b3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" align="left" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 55%;">
                <div>&#160;</div>
              </td>
              <td colspan="2" rowspan="1">
                <div>&#160;Very truly yours,</div>
              </td>
            </tr>
            <tr>
              <td style="width: 55%;">
                <div>&#160;</div>
              </td>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 42%;">
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 55%;">
                <div>&#160;</div>
              </td>
              <td colspan="2" rowspan="1">
                <div>&#160;CENTERVIEW PARTNERS LLC</div>
              </td>
            </tr>
            <tr>
              <td style="width: 55%;">
                <div>&#160;</div>
              </td>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 42%;">
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 55%;">
                <div>&#160;</div>
              </td>
              <td style="width: 3%;">
                <div>&#160;By:</div>
              </td>
              <td style="width: 42%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div>&#160;/s/ Centerview Partners LLC</div>
              </td>
            </tr>

        </table>
        <div style="clear: both;"> <br>
        </div>
        <div> <br>
        </div>
        June 30, 2021</div>
      <div style="font-family: 'Times New Roman',Times,serif;"> <br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif;"> <br>
      </div>
    </div>
    <br>
    <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>6
<FILENAME>nt10026444x1_ex99-2.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.5.1.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 99.2</font><br>
    </div>
  </div>
  <div>
    <table id="z403737fd353f42f495b9a311d827830a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 75%; text-align: left; vertical-align: bottom;">
            <div>BofA Securities, Inc.<br>
            </div>
          </td>
          <td style="width: 25%;">
            <div>BofA SECURITIES<br>
              GLOBAL CORPORATE &amp; <br>
              INVESTMENT BANKING<br>
            </div>
          </td>
        </tr>

    </table>
  </div>
  <div><br>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin: 0px; font-family: 'Times New Roman',Times,serif; text-align: right;">June 30, 2021</div>
    <div><br>
    </div>
    <div>Board of Directors</div>
    <div>PRA Health Sciences, Inc.</div>
    <div>4130 ParkLake Avenue, Suite 400</div>
    <div>
      <div>Raleigh, NC 27612</div>
    </div>
    <div>
      <div><br>
      </div>
      <div>Members of the Board of Directors:</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">We hereby consent to the inclusion of our opinion letter, dated February 24, 2021, to the Board of Directors of PRA Health Sciences, Inc. (&#8220;PRA&#8221;) as Annex C to, and to the reference thereto under the headings
        &#8220;Summary&#8212;Opinions of PRA&#8217;s Financial Advisors&#8221;, &#8220;The Merger&#8212;Background of the Merger&#8221;, &#8220;The Merger&#8212;Recommendation of the PRA Board of Directors and Reasons for the Merger&#8221;, &#8220;The Merger&#8212;Opinions of PRA&#8217;s Financial Advisors&#8221;, &#8220;The Merger
        Proposal&#8212;ICON Unaudited Financial Forecasts&#8221; and &#8220;The Merger Proposal&#8212;PRA Unaudited Financial Forecasts&#8221; in, the joint proxy statement/prospectus relating to the proposed merger involving PRA, ICON plc (&#8220;ICON&#8221;), ICON US Holdings, Inc. (&#8220;US HoldCo&#8221;)
        and Indigo Merger Sub, Inc., a wholly owned subsidiary of ICON and US HoldCo, which joint proxy statement/prospectus forms a part of ICON&#8217;s Registration Statement on Form F&#8209;4 (Registration No. 333-254891) (the &#8220;Prior Registration Statement&#8221;), filed
        on March 31, 2021, and declared effective as of April 27, 2021, and which Prior Registration Statement is incorporated by reference in ICON&#8217;s Registration Statement on Form F&#8209;4 to which this consent is filed as an exhibit (the &#8220;Subsequent
        Registration Statement&#8221;).&#160; In giving the foregoing consent, we do not admit (1) that we come within the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), or the rules and
        regulations of the Securities and Exchange Commission (the &#8220;Commission&#8221;) promulgated thereunder, or (2) that we are experts with respect to any part of the Subsequent Registration Statement within the meaning of the term &#8220;experts&#8221; as used in the
        Securities Act and the rules and regulations of the Commission promulgated thereunder.</div>
    </div>
    <div>
      <div><br>
      </div>
      <div>Very truly yours,</div>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <table id="zc121766e8eae4cd7ac7ed5df58c9d945" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 25%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div>/s/ BOFA SECURITIES, INC.<br>
                </div>
              </td>
              <td style="width: 75%; padding-bottom: 2px;">
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 25%;">
                <div>BOFA SECURITIES, INC.</div>
              </td>
              <td style="width: 75%;">
                <div>&#160;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
  </div>
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<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>7
<FILENAME>nt10026444x1_ex99-3.htm
<DESCRIPTION>EXHIBIT 99.3
<TEXT>
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    <title></title>
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    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 99.3</font><br>
    </div>
  </div>
  <div> <br>
  </div>
  <div>
    <div style="text-align: center; font-weight: bold;">CONSENT OF UBS SECURITIES LLC</div>
    <div><br>
    </div>
    <div>We hereby consent to the use of our opinion letter dated February 24, 2021 to the Board of Directors of PRA Health Sciences, Inc. (&#8220;PRA&#8221;) included as Annex D to the Joint Proxy Statement/Prospectus, which forms a part of the Registration Statement
      (File No. 333-254891), including all amendments, supplements and exhibits thereto, of ICON plc (&#8220;ICON&#8221;) on Form F-4 relating to the proposed merger of PRA and ICON (the &#8220;Prior Registration Statement&#8221;), and references to such opinion in such Joint
      Proxy Statement/Prospectus, which contents of such Prior Registration Statement, including such Joint Proxy Statement/Prospectus, are incorporated by reference into the Registration Statement of ICON on Form F-4 filed for the sole purpose of
      registering additional ICON ordinary shares estimated to be issuable upon the completion of the merger described in the Prior Registration Statement. In giving such consent, we do not admit that we come within the category of persons whose consent is
      required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Securities and Exchange Commission thereunder, nor do we thereby admit that we are experts with respect to any part of such Registration Statement
      within the meaning of the term &#8220;Experts&#8221; as used in the Securities Act of 1933, as amended, or the rules and regulations of the Securities and Exchange Commission thereunder.</div>
    <div><br>
    </div>
    <div>
      <table id="zda1772d9a45645d18f7b8c5bd9a5dce7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50%; padding-bottom: 2px;">
              <div>&#160;</div>
            </td>
            <td style="width: 25%; border-bottom: 2px solid rgb(0, 0, 0);">
              <div>/s/ UBS SECURITIES LLC </div>
            </td>
            <td colspan="1" style="width: 25%; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 25%;">
              <div>UBS SECURITIES LLC <br>
              </div>
            </td>
            <td colspan="1" style="width: 25%;">&#160;</td>
          </tr>

      </table>
    </div>
    <div style="margin-left: 339.75pt;"> <br>
    </div>
    <br>
    <div>New York, New York</div>
    <div>June 30, 2021</div>
    <div><br>
    </div>
    <div><br>
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      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>nt10026444x1_ex5-1img01.jpg
<TEXT>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
