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Property, Plant and Equipment, net
 12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment, net Property, Plant and Equipment, net
December 31, 2021December 31, 2020
 (in thousands)
Cost  
Land$3,724 $3,724 
Building82,017 90,139 
Computer equipment and software506,322 440,930 
Office furniture and fixtures107,507 91,933 
Laboratory equipment29,210 44,567 
Leasehold improvements70,123 32,261 
Motor vehicles65 160 
 798,968 703,714 
Less accumulated depreciation and asset write offs(462,524)(529,371)
Property, plant and equipment (net)$336,444 $174,343 

The Company regularly updates its register of property, plant and equipment and during the year ended December 31, 2021 and the year ended December 31, 2020, certain fully depreciated assets were written off as they were no longer used in the Company.