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Net Income Per Ordinary Share
 12 Months Ended
Dec. 31, 2021
Earnings Per Share [Abstract]  
Net income per ordinary share Net income per ordinary share
Basic net income per ordinary share attributable to the Group has been computed by dividing net income available to ordinary shareholders by the weighted average number of ordinary shares outstanding during the period.
    
Diluted net income per ordinary share is computed by adjusting the weighted average number of ordinary shares outstanding during the period for all potentially dilutive ordinary shares outstanding during the period and adjusting net income for any changes in income or loss that would result from the conversion of such potential ordinary shares.
    
There is no difference in net income used for basic and diluted net income per ordinary share.
    
Basic and diluted net income per ordinary share attributable to the Group for the years ended December 31, 2020 and December 31, 2019 include the adjustment to reflect the accretion of the noncontrolling interest in MeDiNova to its redemption value. The noncontrolling interest was acquired in the year ended December 31, 2020 and therefore no adjustment has been required in the year ended December 31, 2021.
    
The reconciliation of the number of shares used in the computation of basic and diluted net income per ordinary share is as follows:
December 31, 2021December 31, 2020December 31, 2019
Weighted average number of ordinary shares outstanding for basic net income per ordinary share67,110,186 52,859,911 53,859,537 
Effect of dilutive share options outstanding958,125 423,674 473,924 
Weighted average number of ordinary shares outstanding for diluted net income per ordinary share68,068,311 53,283,585 54,333,461 
The reconciliation between net income attributable to the Group per the Consolidated Statement of Operations and the net income used to calculate net income per ordinary share attributable to the Group is as follows:
December 31, 2021December 31, 2020December 31, 2019
(in thousands)
Net income attributable to the Group$153,185 332,331 $373,986 
Noncontrolling interest adjustment to redemption amount— (4,522)(5,048)
Net income attributable to the Group (including NCI redemption adjustment)153,185 327,809 368,938 
December 31, 2021December 31, 2020December 31, 2019
Net income per Ordinary Share attributable to the Group (including NCI redemption adjustment):
Basic $2.28 $6.20 $6.85 
Diluted $2.25 $6.15 $6.79