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Significant accounting policies - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Mar. 09, 2020
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Goodwill impairment charge	$ 0	$ 0	$ 0
Carrying value of inventory	$ 5,800,000	$ 4,800,000
MeDiNova
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Business combination acquisition percentage (in percent)				100.00%

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Percentage of voting equity interests acquired in a business combination achieved in stages, including equity interests in the acquiree held by the acquirer immediately before the acquisition date and acquired at the acquisition date.

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Amount of loss from the write-down of an asset representing the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.

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