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Significant accounting policies - Estimated Useful Lives of Assets (Details)
12 Months Ended
Dec. 31, 2021
Building    
Property, Plant and Equipment [Line Items]  
Estimated useful lives 40 years
Computer equipment and software | Minimum  
Property, Plant and Equipment [Line Items]  
Estimated useful lives 2 years
Computer equipment and software | Maximum  
Property, Plant and Equipment [Line Items]  
Estimated useful lives 8 years
Office furniture and fixtures  
Property, Plant and Equipment [Line Items]  
Estimated useful lives 8 years
Laboratory equipment    
Property, Plant and Equipment [Line Items]  
Estimated useful lives 5 years
Motor vehicles  
Property, Plant and Equipment [Line Items]  
Estimated useful lives 5 years