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Equity Incentive Schemes and Stock Compensation Charges - Outstanding and Exercisable Share Options (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) $ 14.80      
Maximum Range Exercise Price (USD per share) 231.08      
Range 1        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 14.80      
Maximum Range Exercise Price (USD per share) 97.30      
Range 2        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 103.81      
Maximum Range Exercise Price (USD per share) 124.00      
Range 3        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 125.74      
Maximum Range Exercise Price (USD per share) 147.26      
Range 4        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 159.33      
Maximum Range Exercise Price (USD per share) $ 231.08      
Stock Option and Award Plans        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 1,695,460      
Weighted Average Remaining Contractual Life 5 years 4 months 20 days      
Weighted average exercise price (USD per share) $ 104.79 $ 108.53 $ 87.80 $ 74.32
Number of Shares (in shares) 989,419      
Vested and exercisable at end of period (USD per share) $ 91.70      
Stock Option and Award Plans | Range 1        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 638,118      
Weighted Average Remaining Contractual Life 3 years 5 months 12 days      
Number of Shares (in shares) 605,624      
Stock Option and Award Plans | Range 2        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 320,310      
Weighted Average Remaining Contractual Life 6 years 5 months 26 days      
Number of Shares (in shares) 130,920      
Stock Option and Award Plans | Range 3        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 540,296      
Weighted Average Remaining Contractual Life 6 years 6 months 21 days      
Number of Shares (in shares) 235,808      
Stock Option and Award Plans | Range 4        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 196,736      
Weighted Average Remaining Contractual Life 6 years 8 months 4 days      
Number of Shares (in shares) 17,067