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Property, Plant and Equipment, net | 12 Months Ended
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Dec. 31, 2022
Property, Plant and Equipment [Abstract] |
Property, Plant and Equipment, net | Property, Plant and Equipment, net The carrying amount of Property, Plant and Equipment for the years ended December 31, 2022 and 2021 is as follows:
| December 31, 2022 | December 31, 2021
| (in thousands)
Cost |  |
Land | $ | 3,724 |  | $ | 3,724 |
Building | 70,880 |  | 82,017 |
Computer equipment and software | 500,135 |  | 506,322 |
Office furniture and fixtures | 50,600 |  | 107,507 |
Laboratory equipment | 59,946 |  | 29,210 |
Leasehold improvements | 65,167 |  | 70,123 |
Motor vehicles | 41 |  | 65 |
| 750,493 |  | 798,968 |
Less accumulated depreciation and asset write offs | (400,173) |  | (462,524) |
Property, plant and equipment (net) | $ | 350,320 |  | $ | 336,444 |
Property, Plant and Equipment depreciation expense is as follows:
| December 31, 2022 | December 31, 2021
| (in thousands)
Depreciation expense | $ | 106,426 |  | $ | 75,484 |
The Company regularly updates its register of property, plant and equipment and during the year ended December 31, 2022 and the year ended December 31, 2021, certain fully depreciated assets were written off as they were no longer used in the Company.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI https://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI https://asc.fasb.org/extlink&oid=126982197&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99779-112916 + Details
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