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Equity Incentive Schemes and Stock Compensation Charges - Outstanding and Exercisable Share Options (Details) - $ / shares
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) $ 14.88      
Maximum Range Exercise Price (USD per share) 231.68      
Range 1        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 14.88      
Maximum Range Exercise Price (USD per share) 96.15      
Range 2        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 103.81      
Maximum Range Exercise Price (USD per share) 124.00      
Range 3        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 125.74      
Maximum Range Exercise Price (USD per share) 147.26      
Range 4        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Minimum Range Exercise Price (USD per share) 159.33      
Maximum Range Exercise Price (USD per share) $ 231.68      
Stock Option and Award Plans        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 1,378,119      
Weighted Average Remaining Contractual Life 4 years 8 months 8 days      
Weighted average exercise price (USD per share) $ 119.86 $ 110.38 $ 108.53 $ 87.80
Number of Shares (in shares) 1,047,803      
Vested and exercisable at end of period (USD per share) $ 102.29      
Stock Option and Award Plans | Range 1        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 494,565      
Weighted Average Remaining Contractual Life 2 years 8 months 12 days      
Number of Shares (in shares) 494,565      
Stock Option and Award Plans | Range 2        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 226,489      
Weighted Average Remaining Contractual Life 5 years 6 months 29 days      
Number of Shares (in shares) 203,605      
Stock Option and Award Plans | Range 3        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 386,518      
Weighted Average Remaining Contractual Life 5 years 7 months 24 days      
Number of Shares (in shares) 303,054      
Stock Option and Award Plans | Range 4        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of Shares (in shares) 270,547      
Weighted Average Remaining Contractual Life 6 years 2 months 26 days      
Number of Shares (in shares) 46,579