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Property, Plant and Equipment, net
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment, net Property, Plant and Equipment, net
The carrying amount of Property, Plant and Equipment for the years ended December 31, 2022 and 2021 is as follows:
December 31, 2022December 31, 2021
 (in thousands)
Cost  
Land$3,724 $3,724 
Building70,880 82,017 
Computer equipment and software500,135 506,322 
Office furniture and fixtures50,600 107,507 
Laboratory equipment59,946 29,210 
Leasehold improvements65,167 70,123 
Motor vehicles41 65 
 750,493 798,968 
Less accumulated depreciation and asset write offs(400,173)(462,524)
Property, plant and equipment (net)$350,320 $336,444 

Property, Plant and Equipment depreciation expense is as follows:
December 31, 2022December 31, 2021
 (in thousands)
Depreciation expense$106,426 $75,484 

The Company regularly updates its register of property, plant and equipment and during the year ended December 31, 2022 and the year ended December 31, 2021, certain fully depreciated assets were written off as they were no longer used in the Company.