<SEC-DOCUMENT>0001140361-25-004252.txt : 20250213
<SEC-HEADER>0001140361-25-004252.hdr.sgml : 20250213
<ACCEPTANCE-DATETIME>20250213145012
ACCESSION NUMBER:		0001140361-25-004252
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250213
DATE AS OF CHANGE:		20250213

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Onconetix, Inc.
		CENTRAL INDEX KEY:			0001782107
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-93586
		FILM NUMBER:		25619550

	BUSINESS ADDRESS:	
		STREET 1:		201 E. FIFTH STREET
		STREET 2:		SUITE 1900
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45202
		BUSINESS PHONE:		513-620-4101

	MAIL ADDRESS:	
		STREET 1:		201 E. FIFTH STREET
		STREET 2:		SUITE 1900
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45202

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Blue Water Biotech, Inc.
		DATE OF NAME CHANGE:	20230424

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Blue Water Vaccines Inc.
		DATE OF NAME CHANGE:	20190710

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMERICAN FINANCIAL GROUP INC
		CENTRAL INDEX KEY:			0001042046
		STANDARD INDUSTRIAL CLASSIFICATION:	FIRE, MARINE & CASUALTY INSURANCE [6331]
		ORGANIZATION NAME:           	02 Finance
		IRS NUMBER:				311544320
		STATE OF INCORPORATION:			OH
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		GREAT AMERICAN INSURANCE GROUP TOWER
		STREET 2:		301 E. 4TH STREET
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45202
		BUSINESS PHONE:		5135792121

	MAIL ADDRESS:	
		STREET 1:		GREAT AMERICAN INSURANCE GROUP TOWER
		STREET 2:		301 E. 4TH STREET
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45202

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN FINANCIAL GROUP HOLDINGS INC
		DATE OF NAME CHANGE:	19970709
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<submissionType>SCHEDULE 13G/A</submissionType>
<previousAccessionNumber>0001140361-24-003954</previousAccessionNumber>
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<formData>
<coverPageHeader>
<amendmentNo>2</amendmentNo>
<securitiesClassTitle>Common, $0.00001 par value</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0001782107</issuerCik>
<issuerName>ONCONETIX, INC.</issuerName>
<issuerCusip>09610B108</issuerCusip>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>201 East Fifth Street, Suite 1900</com:street1>
<com:city>Cincinnati</com:city>
<com:stateOrCountry>OH</com:stateOrCountry>
<com:zipCode>45202</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
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<reportingPersonName>AMERICAN FINANCIAL GROUP INC</reportingPersonName>
<memberGroup>b</memberGroup>
<citizenshipOrOrganization>OH</citizenshipOrOrganization>
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<soleVotingPower>36023</soleVotingPower>
<sharedVotingPower>0</sharedVotingPower>
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<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>36023</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>0</classPercent>
<typeOfReportingPerson>HC</typeOfReportingPerson>
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<issuerName>ONCONETIX, INC.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>201 East Fifth Street, Suite 1900, Cincinnati, Ohio, 45202</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>American Financial Group, Inc. ("AFG")</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>Great American Insurance Group Tower, &#13;
301 East Fourth Street, Cincinnati, Ohio  45202</principalBusinessOfficeOrResidenceAddress>
<citizenship>U.S.A. - Ohio</citizenship>
</item2>
<item3>
<notApplicableFlag>N</notApplicableFlag>
<typeOfPersonFiling>HC</typeOfPersonFiling>
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<amountBeneficiallyOwned>36,023</amountBeneficiallyOwned>
<classPercent>0.0</classPercent>
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<solePowerOrDirectToVote>36,023</solePowerOrDirectToVote>
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<solePowerOrDirectToDispose>36,023</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
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<item5>
<notApplicableFlag>N</notApplicableFlag>
<classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
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<notApplicableFlag>Y</notApplicableFlag>
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<notApplicableFlag>N</notApplicableFlag>
<subsidiaryIdentificationAndClassification>Great American Insurance Company (IC-Ohio)</subsidiaryIdentificationAndClassification>
</item7>
<item8>
<notApplicableFlag>Y</notApplicableFlag>
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<item9>
<notApplicableFlag>Y</notApplicableFlag>
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<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
</item10>
</items>
<signatureInformation>
<reportingPersonName>AMERICAN FINANCIAL GROUP INC</reportingPersonName>
<signatureDetails>
<signature>/s/ Mark A. Weiss</signature>
<title>Mark A. Weiss, Senior Vice President</title>
<date>02/13/2025</date>
</signatureDetails>
</signatureInformation>
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</SEC-DOCUMENT>
