<SEC-DOCUMENT>0001144204-16-082673.txt : 20160216
<SEC-HEADER>0001144204-16-082673.hdr.sgml : 20160215
<ACCEPTANCE-DATETIME>20160216162429
ACCESSION NUMBER:		0001144204-16-082673
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160216
DATE AS OF CHANGE:		20160216
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ascendis Pharma A/S
		CENTRAL INDEX KEY:			0001612042
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			G7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88586
		FILM NUMBER:		161428844

	BUSINESS ADDRESS:	
		STREET 1:		TUBORG BOULEVARD 12
		CITY:			HELLERUP
		STATE:			G7
		ZIP:			DK-2900
		BUSINESS PHONE:		45 36 94 44 86

	MAIL ADDRESS:	
		STREET 1:		TUBORG BOULEVARD 12
		CITY:			HELLERUP
		STATE:			G7
		ZIP:			DK-2900

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v431516_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
<HTML>
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<P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">UNITED STATES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Under the Securities Exchange Act of 1934</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0in"><B>(Amendment No. 1)*</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Ascendis Pharma A/S&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>American Depository Shares representing
Ordinary Shares of Ascendis Pharma A/S</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>04351P101&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>December 31, 2015</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;(Date of Event Which Requires Filing of this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD><TD>Rule 13d-1(b)</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD><TD>Rule 13d-1(c)</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD><TD>Rule 13d-1(d)</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">*The remainder of this cover page shall be
filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information required in the remainder of
this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934
(&ldquo;<B><I>Act</I></B>&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all
other provisions of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="width: 30%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">CUSIP
    No. <B>04351P101</B></FONT></TD>
    <TD STYLE="width: 40%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G</B></FONT></TD>
    <TD STYLE="width: 30%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 1pt solid; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>RA Capital Management, LLC</B></P></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2. </FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 0; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="width: 83%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">3.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only </FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Massachusetts</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD ROWSPAN="7" STYLE="width: 15%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shares</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Owned by</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Person With</FONT></TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">5.</FONT></TD>
    <TD STYLE="width: 78%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">6.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1,671,447 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">7.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">8.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1,671,447 shares</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">9.</FONT></TD>
    <TD STYLE="width: 88%; padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>1,671,447 shares</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">10.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Check
        if the Aggregate Amount in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&uml;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">11.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>6.7%</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">12.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>IA</B></P></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>


<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>

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    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 30%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">CUSIP No. <B>04351P101</B></P></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; width: 40%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G</B></FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 30%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>Peter Kolchinsky</B></P></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2. </FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 0; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="width: 83%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">3.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only </FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>United States</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD ROWSPAN="7" STYLE="width: 15%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shares</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Owned by</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Person With</FONT></TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">5.</FONT></TD>
    <TD STYLE="width: 78%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">6.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1,671,447 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">7.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">8.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1,671,447 shares</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">9.</FONT></TD>
    <TD STYLE="width: 88%; padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>1,671,447 shares</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">10.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Check
if the Aggregate Amount in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">11.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>6.7%</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">12.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>IN</B></P></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>


<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 30%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">CUSIP No. <B>04351P101</B></FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; width: 40%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G</B></FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 30%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>RA Capital Healthcare Fund, L.P.</B></P></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2. </FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 1.45pt; padding-right: 0; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="width: 83%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">3.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only </FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Delaware</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD ROWSPAN="7" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 15%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shares</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Owned by</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Person With</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 7%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">5.</FONT></TD>
    <TD STYLE="width: 78%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">6.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>&nbsp;1,458,758 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">7.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">8.</FONT></TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1,458,758 shares</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 5%">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; width: 7%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">9.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt; width: 88%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>1,458,758 shares</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">10.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Check
if the Aggregate Amount in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">11.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>5.8%</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">12.</FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt -0.25in; text-indent: 0.5in"><B>PN (Limited Partnership)</B></P></TD></TR>
<TR>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 1.45pt 3pt; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0"></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">CUSIP <FONT STYLE="font-family: Times New Roman, Times, Serif">No. <B>04351P101</B></FONT></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Name
of Issuer:</B> Ascendis Pharma A/S (the &ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Address
of the Issuer&rsquo;s Principal Executive Offices:</B> <FONT STYLE="background-color: white">Tuborg Boulevard 12, DK-2900 Hellerup,
Denmark</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 2.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Name
of Person Filing: </B> This joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC (&ldquo;Capital&rdquo;),
and RA Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;). Mr. Kolchinsky, Capital and the Fund are collectively referred to
herein as the &ldquo;Reporting Persons.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Address
of Principal Business Office:</B> The principal business office of the Reporting Persons is c/o RA Capital Management, LLC, 20
Park Plaza, Suite 1200, Boston, MA 02116.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Citizenship:</B>
Capital is a Massachusetts limited liability company. The Fund is a Delaware limited partnership. Mr. Kolchinsky is a United States
citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Title
and Class of Securities: </B>American Depositary Receipts (&ldquo;ADR&rdquo;) of the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0in">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>CUSIP
Number: </B>04351P101</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If
this statement is filed pursuant to &sect;&sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 4. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Ownership:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Provide the following information regarding
the aggregate number and percentage of the class of securities of the issuer identified in Item 1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font-size: 10pt">(a)</TD>
    <TD STYLE="width: 95%; font-size: 10pt">Amount Beneficially Owned:**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. &ndash; 1,458,758 shares</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-left: 0.5in; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">(b)</TD>
    <TD STYLE="font-size: 10pt">Percent of Class:**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC &ndash; 6.7%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky &ndash; 6.7%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. &ndash; 5.8%</P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">CUSIP
No. <B>04351P101</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>(c)</TD>
    <TD COLSPAN="2">Number of shares as to which such person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 5%">(i)</TD>
    <TD STYLE="width: 90%">sole power to vote or to direct the vote **</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. - 0 shares</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 0.5in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>(ii)</TD>
    <TD>shared power to vote or to direct the vote**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. &ndash; 1,458,758 shares</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 0.5in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>(iii)</TD>
    <TD>sole power to dispose or to direct the disposition of**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. - 0 shares</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 0.5in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>(iv)</TD>
    <TD>shared power to dispose or to direct the disposition of**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Management, LLC &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">Peter Kolchinsky &ndash; 1,671,447 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in">RA Capital Healthcare Fund, L.P. &ndash; 1,458,758 shares</P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">** <FONT STYLE="font-size: 10pt">RA Capital
Management, LLC (&ldquo;Capital&rdquo;) is the general partner of RA Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;) and
serves as investment adviser for a separately managed account (the &ldquo;Account&rdquo;). Peter Kolchinsky is the manager of Capital.
Mr. Kolchinsky, Capital and the Fund are referred to herein collectively as the &ldquo;Reporting Persons.&rdquo; As the investment
adviser to the Fund and the Account, Capital may be deemed a beneficial owner, for purposes of Section 13(d) of the Securities
Exchange Act of 1934 (the &ldquo;Act&rdquo;), of any securities of the Issuer owned by the Fund or the Account. As the manager
of Capital, Mr. Kolchinsky may be deemed a beneficial owner, for purposes of Section 13(d) of the Act, of any securities of the
Issuer beneficially owned by Capital. Capital is a registered investment adviser within the meaning of Rule 13d-1(b)(1)(ii)(E)
and Rule 16a-1(a)(v), and Mr. Kolchinsky is a parent or control person of Capital within the meaning of Rule 13d-1(b)(1)(ii)(G)
and Rule 16a-1(a)(1)(vii). Capital and Mr. Kolchinsky disclaim beneficial ownership of the securities reported in this Schedule
13G Statement (the &ldquo;Statement&rdquo;) other than for the purpose of determining their obligations under Section 13(d) of
the Act, and neither the filing of the Statement nor the filing of this Amendment shall not be deemed an admission that either
Capital or Mr. Kolchinsky is or was the beneficial owner of such securities for any other purpose. </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 5.</B></TD><TD STYLE="text-align: justify"><B>Ownership of Five Percent or Less of a Class:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: justify; text-indent: -1in"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 6.</B></TD><TD STYLE="text-align: justify"><B>Ownership of More than Five Percent on Behalf of Another
Person:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">CUSIP <FONT STYLE="font-family: Times New Roman, Times, Serif">No. <B>04351P101</B></FONT></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Identification
and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 8.</B></TD><TD STYLE="text-align: justify"><B>Identification and Classification of Members of the
Group:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 9.</B></TD><TD STYLE="text-align: justify"><B>Notice of Dissolution of Group:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 10.</B></TD><TD STYLE="text-align: justify"><B>Certification:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">By signing below I hereby certify that, to
the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or
with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><U>Exhibits</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">1</TD><TD>Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule
13G filed by the Reporting Persons with the Securities and Exchange Commission on May 08<FONT STYLE="text-transform: uppercase">,
2015</FONT>.</TD></TR></TABLE>
<P STYLE="margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-decoration: none"><FONT STYLE="text-transform: uppercase">Date: </FONT>February 16, 2016</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">RA CAPITAL MANAGEMENT, LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%">By:</TD>
    <TD STYLE="width: 47%; border-bottom: Black 1pt solid">/s/ Rajeev Shah</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Rajeev Shah</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Authorized Signatory</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">PETER KOLCHINSKY</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/ Peter Kolchinsky</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">RA CAPITAL HEALTHCARE FUND, L.P.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">By: RA Capital Management, LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Its: General Partner</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid">/s/ Rajeev Shah</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Rajeev Shah</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Authorized Signatory</TD></TR>
</TABLE>
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