<SEC-DOCUMENT>0001144204-16-107313.txt : 20160607
<SEC-HEADER>0001144204-16-107313.hdr.sgml : 20160607
<ACCEPTANCE-DATETIME>20160607165150
ACCESSION NUMBER:		0001144204-16-107313
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160607
DATE AS OF CHANGE:		20160607
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ascendis Pharma A/S
		CENTRAL INDEX KEY:			0001612042
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			G7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88586
		FILM NUMBER:		161701832

	BUSINESS ADDRESS:	
		STREET 1:		TUBORG BOULEVARD 5
		CITY:			HELLERUP
		STATE:			G7
		ZIP:			DK-2900
		BUSINESS PHONE:		45 36 94 44 86

	MAIL ADDRESS:	
		STREET 1:		TUBORG BOULEVARD 5
		CITY:			HELLERUP
		STATE:			G7
		ZIP:			DK-2900

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v441943_sc13g-a.htm
<DESCRIPTION>SC 13G/A
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Under the Securities Exchange Act of
1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><B>(Amendment No. 2)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><BR>
Ascendis Pharma A/S&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>American Depository Shares representing
Ordinary Shares of Ascendis Pharma A/S</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;(Title
of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>04351P101&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>June 3, 2016&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event Which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif">
<tr>
    <TD STYLE="padding: 3pt">[ &nbsp; ]</td>
    <TD STYLE="padding: 3pt">Rule 13d-1(b)</td></tr>
<tr>
    <td style="padding: 3pt">[<b>X</b>]</td>
    <td style="padding: 3pt">Rule 13d-1(c)</td></tr>
<tr>
    <td style="padding: 3pt">[ &nbsp; ]</td>
    <td style="padding: 3pt">Rule 13d-1(d)</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">*The remainder of this cover page shall
be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The information required in the remainder
of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of
1934 (&ldquo;<B><I>Act</I></B>&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject
to all other provisions of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">CUSIP No. </font><b>04351P101</b></td>
    <td style="padding: 1.45pt 3pt; text-align: center"><font style="font-size: 12pt"><b>13G</b></font></td>
    <td style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">1.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>RA Capital Management, LLC&#9;</b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">2. </font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(a)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <TD STYLE="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(b)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">3.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">4.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>Massachusetts</b></font></td></tr>
<tr>
    <td colspan="3" rowspan="7" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">5.</font></td>
    <td colspan="3"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">6.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>2,927,857 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">7.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">8.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>2,927,857 </b></font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">9.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>2,927,857 </b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">10.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </font>[_]</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">11.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>11.6%<sup>1</sup></b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">12.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IA</b></P></td></tr>
<tr>
    <td style="width: 4%">&nbsp;</td>
    <td style="width: 7%">&nbsp;</td>
    <td style="width: 6%">&nbsp;</td>
    <td style="width: 3%">&nbsp;</td>
    <td style="width: 23%">&nbsp;</td>
    <td style="width: 22%">&nbsp;</td>
    <td style="width: 35%">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">___________________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><SUP>1</SUP> The reporting person is the beneficial owner of
2,927,857 of the Issuer&rsquo;s American Depository Shares (&ldquo;ADSs&rdquo;) representing 2,927,857 of the Issuer&rsquo;s ordinary
shares, which constitute approximately 11.6% of the Issuer&rsquo;s outstanding ordinary shares. The percentage calculation assumes
that there are currently 25,162,873 outstanding ordinary shares of the Issuer, based on the Issuer&rsquo;s Form F-3 as filed with
the Securities and Exchange Commission (&ldquo;SEC&rdquo;) on May 20, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">CUSIP No. </font><b>04351P101</b></td>
    <td style="padding: 1.45pt 3pt; text-align: center"><font style="font-size: 12pt"><b>13G</b></font></td>
    <td style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">1.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>Peter Kolchinsky&#9;</b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">2. </font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(a)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <TD STYLE="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(b)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">3.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">4.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<b>United States</b></td></tr>
<tr>
    <td colspan="3" rowspan="7" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">5.</font></td>
    <td colspan="3"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">6.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>2,927,857 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">7.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">8.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>2,927,857 </b></font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">9.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>2,927,857 </b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">10.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </font>[_]</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">11.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>11.6%<sup>1</sup></b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">12.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IN</b></P></td></tr>
<tr>
    <td style="width: 4%">&nbsp;</td>
    <td style="width: 7%">&nbsp;</td>
    <td style="width: 6%">&nbsp;</td>
    <td style="width: 3%">&nbsp;</td>
    <td style="width: 23%">&nbsp;</td>
    <td style="width: 22%">&nbsp;</td>
    <td style="width: 35%">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">______________________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><SUP>1</SUP> <FONT STYLE="font-size: 10pt">The reporting person
is the beneficial owner of 2,927,857 of the Issuer&rsquo;s ADSs representing 2,927,857 of the Issuer&rsquo;s ordinary shares, which
constitute approximately 11.6% of the Issuer&rsquo;s outstanding ordinary shares. The percentage calculation assumes that there
are currently 25,162,873 outstanding ordinary shares of the Issuer, based on the Issuer&rsquo;s Form F-3 as filed with the SEC
on May 20, 2016.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">CUSIP No. </font>&nbsp;<b>04351P101</b></td>
    <td style="padding: 1.45pt 3pt; text-align: center"><font style="font-size: 12pt"><b>13G</b></font></td>
    <td style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">1.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>RA Capital Healthcare Fund, L.P.&#9;</b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="vertical-align: top; padding: 1.45pt 3pt"><font style="font-size: 10pt">2. </font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(a)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <TD STYLE="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(b)</font></td>
    <td colspan="4" style="padding-bottom: 6pt">[_]</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">3.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">4.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>Delaware</b></font></td></tr>
<tr>
    <td colspan="3" rowspan="7" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">5.</font></td>
    <td colspan="3"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">6.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>&nbsp;2,155,159 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">7.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 </b></font></td></tr>
<tr>
    <td colspan="4" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">8.</font></td>
    <td colspan="3" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>2,155,159 </b></font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">9.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>2,155,159 </b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">10.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </font>[_]</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">11.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>8.6%<sup>1</sup></b></P></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">12.</font></td>
    <td colspan="5" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>PN (Limited Partnership)</b></P></td></tr>
<tr>
    <td style="width: 4%">&nbsp;</td>
    <td style="width: 7%">&nbsp;</td>
    <td style="width: 6%">&nbsp;</td>
    <td style="width: 3%">&nbsp;</td>
    <td style="width: 23%">&nbsp;</td>
    <td style="width: 22%">&nbsp;</td>
    <td style="width: 35%">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">__________________________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><SUP>1</SUP> <FONT STYLE="font-size: 10pt">The reporting person
is the beneficial owner of 2,155,159 of the Issuer&rsquo;s ADSs representing 2,155,159 of the Issuer&rsquo;s ordinary shares, which
constitute approximately 8.6% of the Issuer&rsquo;s outstanding ordinary shares. The percentage calculation assumes that there
are currently 25,162,873 outstanding ordinary shares of the Issuer, based on the Issuer&rsquo;s Form F-3 as filed with the SEC
on May 20, 2016.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">CUSIP No. <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>04351P101</B></FONT></P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Explanatory Note</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This Amendment No. 2 to the Schedule 13G originally filed on
May 8, 2015 is being filed to report certain of the reporting persons&rsquo; beneficial ownership of greater than 10 percent of
a class of equity securities of the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(a)&#9;<B>Name of Issuer:</B> Ascendis
Pharma A/S (the &ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&#9;<B>Address of the Issuer&rsquo;s Principal Executive
Offices:</B> <FONT STYLE="background-color: white">Tuborg Boulevard 12, DK-2900 Hellerup, Denmark</FONT>.<B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 2.&#9;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">(a)&#9;<B>Name of Person
Filing: </B> This joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC (&ldquo;Capital&rdquo;),
and RA Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;). Mr. Kolchinsky, Capital and the Fund are collectively referred to
herein as the &ldquo;Reporting Persons.&rdquo; <FONT STYLE="font-size: 10pt">Capital is the general partner of the Fund and serves
as investment adviser for a separately managed account (the &ldquo;Account&rdquo;). Mr. Kolchinsky is the manager of Capital. As
the investment adviser to the Fund and the Account, Capital may be deemed a beneficial owner, for purposes of Section 13(d) of
the Securities Exchange Act of 1934 (the &ldquo;Act&rdquo;), of any securities of the Issuer owned by the Fund or the Account.
As the manager of Capital, Mr. Kolchinsky may be deemed a beneficial owner, for purposes of Section 13(d) of the Act, of any securities
of the Issuer beneficially owned by Capital. Capital is a registered investment adviser within the meaning of Rule 13d-1(b)(1)(ii)(E)
and Rule 16a-1(a)(v), and Mr. Kolchinsky is a parent or control person of Capital within the meaning of Rule 13d-1(b)(1)(ii)(G)
and Rule 16a-1(a)(1)(vii). Capital and Mr. Kolchinsky disclaim beneficial ownership of the securities reported in this Schedule
13G Statement (the &ldquo;Statement&rdquo;) other than for the purpose of determining their obligations under Section 13(d) of
the Act, and neither the filing of the Statement nor the filing of this Amendment shall not be deemed an admission that either
Capital or Mr. Kolchinsky is or was the beneficial owner of such securities for any other purpose</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">(b)&#9;<B>Address of
Principal Business Office:</B> The principal business office of the Reporting Persons is c/o RA Capital Management, LLC, 20 Park
Plaza, Suite 1200, Boston, MA 02116.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">(c) &#9;<B>Citizenship:</B>
Capital is a Massachusetts limited liability company. The Fund is a Delaware limited partnership. Mr. Kolchinsky is a United States
citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">(d)&#9;<B>Title and Class
of Securities: </B>American Depositary Shares (&ldquo;ADSs&rdquo;) of the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">(e)&#9;<B>CUSIP Number:
</B>04351P101</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 3.&#9;If this statement is filed
pursuant to &sect;&sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">CUSIP No. <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>04351P101</B></FONT></P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 4. &#9;Ownership:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">(a)</td>
    <td colspan="2" style="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Amount Beneficially Owned:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 9 on the attached cover page(s).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td>
    <td colspan="2" style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(b)</td>
    <td colspan="2" style="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 11 on the attached cover page(s).</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</td>
    <td colspan="2" style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(c)</td>
    <td colspan="2" style="padding-right: 2.7pt; padding-left: 2.7pt">Number of shares as to which such person has:</td></tr>
<tr style="vertical-align: top">
    <td style="width: 6%; padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="width: 6%; padding-right: 2.7pt; padding-left: 2.7pt">(i)</td>
    <td style="width: 88%; padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">sole power to vote or to direct the vote:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 5 on the attached cover page(s).</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(ii)</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">shared power to vote or to direct the vote</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 6 on the attached cover page(s).</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(iii)</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">sole power to dispose or to direct the disposition of</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 7 on the attached cover page(s).</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(iv)</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">shared power to dispose or to direct the disposition of</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">See the response(s) to Item 8 on the attached cover page(s).</P></td></tr>
<tr style="vertical-align: top">
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</td>
    <td style="padding-right: 2.7pt; padding-left: 2.7pt">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 5.&#9;Ownership of Five Percent
or Less of a Class:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: justify; text-indent: -1in"><B>Item 6.&#9;Ownership
of More than Five Percent on Behalf of Another Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: justify; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 7. &#9;Identification and Classification
of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">CUSIP No. <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>04351P101</B></FONT></P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 8.&#9;Identification and Classification
of Members of the Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 9.&#9;Notice of Dissolution of
Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 10.&#9;Certification:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">By signing below I hereby certify that,
to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of
or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><U>Exhibits</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">1</TD><TD>Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule
13G filed by the Reporting Persons with the Securities and Exchange Commission on May 8<FONT STYLE="text-transform: uppercase">,
2015</FONT>.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">Date: </FONT>June
7, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><BR>
RA CAPITAL MANAGEMENT, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: /s/ Rajeev Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Rajeev Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Authorized Signatory</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">PETER KOLCHINSKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">/s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">RA CAPITAL HEALTHCARE FUND, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: RA Capital Management, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Its: General Partner</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: /s/ Rajeev Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Rajeev Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Authorized Signatory</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>



<P STYLE="margin: 0"></P>

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