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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenue:      
Royalties $ 232,385 $ 299,004 $ 320,155
Contract revenue 1,666 13,359 3,235
Total revenue 234,051 312,363 323,390
Operating costs and expenses:      
Cost of revenue 28,372 24,085 6,937
Research and development 140,503 115,696 92,706
Marketing, general and administrative 112,594 164,131 119,475
Restructuring costs 7,301 0 0
Impairment of goodwill and long-lived assets 35,471 0 0
Costs of restatement and related legal activities, net 244 16,187 4,190
Gain from settlement 0 (6,200) (126,800)
Total operating costs and expenses 324,485 313,899 96,508
Operating income (loss) (90,434) (1,536) 226,882
Interest income and other income (expense), net 59 563 1,390
Interest expense (27,510) (24,828) (20,228)
Interest and other income (expense), net (27,451) (24,265) (18,838)
Income (loss) before income taxes (117,885) (25,801) 208,044
Provision for income taxes 16,451 17,252 57,127
Net income (loss) $ (134,336) $ (43,053) $ 150,917
Net income (loss) per share:      
Basic (in dollars per share) $ (1.21) $ (0.39) $ 1.34
Diluted (in dollars per share) $ (1.21) $ (0.39) $ 1.30
Weighted average shares used in per share calculations:      
Basic (in shares) 110,769 110,041 112,456
Diluted (in shares) 110,769 110,041 115,884