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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Revenue:        
Royalties $ 69,990 $ 62,835 $ 138,946 $ 125,712
Product revenue 8,401 3,902 19,305 7,214
Contract and other revenue 16,329 9,764 33,820 16,257
Total revenue 94,720 76,501 192,071 149,183
Operating costs and expenses:        
Cost of product revenue [1] 7,480 3,016 12,730 5,550
Cost of contract and other revenue 14,337 11,073 28,818 20,746
Research and development [1] 37,522 28,753 73,522 57,280
Sales, general and administrative [1] 27,137 21,789 55,323 44,884
Gain from settlement 0 (138) 0 (579)
Total operating costs and expenses 86,476 64,493 170,393 127,881
Operating income (loss) 8,244 12,008 21,678 21,302
Interest income and other income (expense), net 129 1,138 283 1,380
Interest expense (3,261) (3,163) (6,467) (6,304)
Interest and other income (expense), net (3,132) (2,025) (6,184) (4,924)
Income before income taxes 5,112 9,983 15,494 16,378
Provision for (benefit from) income taxes 2,507 6,107 9,883 10,624
Net Income (Loss) $ 2,605 $ 3,876 $ 5,611 $ 5,754
Net income per share:        
Earnings Per Share, Basic $ 0.02 $ 0.04 $ 0.05 $ 0.05
Earnings Per Share, Diluted $ 0.02 $ 0.03 $ 0.05 $ 0.05
Weighted average shares used in per share calculation:        
Basic (in shares) 110,060 109,904 110,758 109,818
Diluted (in shares) 112,565 112,061 114,091 112,202
[1] Includes stock-based compensation