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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue: |  |  |  |
Royalties |  | $ 289,594 | $ 264,614 | $ 262,415
Product revenue |  | 36,509 | 26,052 | 17,321
Contract and other revenue |  | 66,993 | 45,931 | 16,542
Total revenue |  | 393,096 | 336,597 | 296,278
Operating costs and expenses: |  |  |  |
Cost of product revenue | [1] | 23,783 | 21,329 | 12,377
Cost of contract and other revenue |  | 55,364 | 45,761 | 32,967
Research and development | [1] | 149,135 | 129,844 | 111,110
Sales, general and administrative | [1] | 110,940 | 95,145 | 70,554
Restructuring charges |  | 0 | 0 | 3,576
Impairment of in-process research and development intangible asset |  | 0 | 18,300 | 0
Change in contingent consideration liability |  | 0 | (6,845) | 0
Gain from sale of intellectual property |  | (533) | 0 | (3,686)
Gain from settlement |  | 0 | (579) | (2,040)
Total operating costs and expenses |  | 338,689 | 302,955 | 224,858
Operating income (loss) |  | 54,407 | 33,642 | 71,420
Interest income (expense), net |  | 1,384 | 1,740 | 1,224
Loss on Extinguishment of Debt |  | (1,082) | 0 | 0
Interest expense |  | (13,720) | (12,745) | (12,413)
Interest and other income (expense), net |  | (13,418) | (11,005) | (11,189)
Income before income taxes |  | 40,989 | 22,637 | 60,231
Provision for (benefit from) income taxes |  | 63,851 | 15,817 | (151,157)
Net income (loss) |  | $ (22,862) | $ 6,820 | $ 211,388
Net income (loss) per share: |  |  |  |
Basic (in dollars per share) |  | $ (0.21) | $ 0.06 | $ 1.84
Diluted (in dollars per share) |  | $ (0.21) | $ 0.06 | $ 1.80
Weighted average shares used in per share calculations: |  |  |  |
Basic (in shares) |  | 110,198 | 110,162 | 114,814
Diluted (in shares) |  | 110,198 | 113,140 | 117,484
[1] | * Includes stock-based compensation: Cost of product revenue$78 $56 $63Research and development$12,185 $9,165 $6,762Sales, general and administrative$15,140 $11,792 $8,271

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